Table 2 IgG-reactivity^a and adjusted MFI^b to four antigens detected in the targeted screening of the complete cohort using antigen bead arrays

Gene description

Keratin associated protein 17-1

Heat shock 70 kDa protein 4

S100 calcium binding protein A12

S100 calcium binding protein Z

Ensembl ENSG ID^c

ENSG00000186860

ENSG00000170606

ENSG00000163221

ENSG00000171643

Uniprot

Q9BYP8

P34932

P80511

Q8WXG8

Protein fragment ID

HPRR3460778

HPRR4220528

HPRR400165

HPRR3460547

AD patients (N = 173)

55 (32)

36 (21)

13 (8)

8 (5)

 Severe^d (N = 50)

20 (40)

15 (30)

5 (10)

7 (14)

 Moderate^d (N = 123)

35 (28)

21 (17)

8 (6)

1 (1)

Healthy controls (N = 84)

13 (15)

9 (11)

0 (0)

3 (4)

AD versus HC

0.006

0.054

0.006

1.00

sAD versus mAD

0.15

0.07

0.53

0.0008

sAD versus HC

0.002

0.009

0.006

0.04

mAD versus HC

0.03

0.23

0.02

0.31

AD patients (N = 173)

7.2 (4.3–18.2)

3.2 (1.3–9.8)

2.6 (0.8–6.5)

− 1.7 (− 2.1 to − 0.6)

 Severe^d (N = 50)

7.4 (4.6–23.3)

4.0 (1.2–21.3)

2.6 (1.0–6.5)

− 1.8 (− 2.2 to 0.5)

 Moderate^d (N = 123)

7.1 (4.3–15.9)

3.2 (1.3–8.7)

2.3 (0.8–6.3)

− 1.7 (− 2.1 to − 1.0)

Healthy Controls (N = 84)

5.8 (3.4–10.5)

2.8 (1.1–7.2)

0.8 (0.2–2.0)

− 1.6 (− 2.0 to − 0.2)

AD versus HC

0.01

0.36

0.000003

0.16

sAD versus mAD

0.26

0.63

0.50

0.35

sAD versus HC

0.01

0.32

0.00008

0.78

mAD versus HC

0.054

0.48

0.00003

0.09