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Table 1 Characterization of the AD patients and healthy controls

From: The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients

 

N

Gender F/M

Age (years)

SCORADa

Rhino-conjunctivitis and/or asthma current or history

Total plasma IgEb ≥ 122 kU/L

Total plasma IgEb (kU/L)

Phadiatop positivec

n (% F)

Median (range)

Median (range)

n (%)

n (%)

Median (range)

n (%)

AD patients

173

99/74 (57)

28 (18–65)

34 (14–70)

139 (80)

95 (55)

160 (2–15,100)

132 (76)

 Severea

50

17/33 (34)

29 (18–65)

54 (41–70)

45 (90)

35 (70)

460 (2.5–15,100)

43 (86)

 Moderatea

123

82/41 (67)

28 (18–63)

31 (14–40)

94 (76)

60 (49)

120 (2–6810)

89 (72)

Healthy controls

84

52/32 (62)

39 (18–65)

NA

0 (0)

0 (0)

19 (2–120)

0 (0)

  1. AD atopic dermatitis, F female, M male, N number of individuals, n number of positive individuals, NA not applicable
  2. aObjective SCORAD [29], severe AD defined as SCORAD ≥ 41
  3. bImmunoCAP (Thermo Fisher Scientific), reference range 1.6–122 kU/L
  4. cPhadiatop (Thermo Fisher Scientific), plasma IgE-reactivity to any of 11 common aeroallergens, reference range ≥ 0.35 kU/L