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Fig. 5 | Clinical and Translational Allergy

Fig. 5

From: The antimicrobial protein S100A12 identified as a potential autoantigen in a subgroup of atopic dermatitis patients

Fig. 5

IgG-reactivity to the antigen representing S100A12 subdivided by Phadiatop and total plasma IgE. Antigen showing significant difference in reactivity between healthy controls (HC) and atopic dermatitis cases (AD) or between HC and moderate (mAD) and/or severe (sAD) atopic dermatitis when analyzed using antigen bead arrays. The frequency (%) of subjects with IgG-reactivity to S100A12 subdivided by Phadiatop (a) or total plasma IgE (b). The adjusted median fluorescence intensity (MFI) of all subjects subdivided by Phadiatop (c) or total plasma IgE (d). Adjusted MFI was defined by subtracting the sample median across all protein fragments from each signal and dividing the result by the MAD. Subjects with positive reactivity are highlighted in red. The number of subjects with positive reactivity out of the total is indicated below each figure. Significant P values of pairwise group comparisons indicated by *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, Fisher’s exact test (a, b) and Wilcoxon-rank sum test (c, d)

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