Fig. 2

Antigens showing significant difference in IgG-reactivity between healthy controls (HC) and atopic dermatitis patients (AD) or between HC and moderate (mAD) and/or severe (sAD) atopic dermatitis patients when analyzed using antigen bead arrays. a The frequency (%) of subjects with IgG-reactivity to KRTAP17-1, HSPA4, S100A12 and S100Z. b The adjusted median fluorescence intensity (MFI) of all subjects with positive reactivity highlighted in red. Adjusted MFI was defined as the sample median across all protein fragments subtracted from each signal and divided by the MAD. The number of subjects with positive reactivity out of the total is indicated below each figure. Significant P values of pairwise group comparisons indicated by *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001, Fisher’s exact test (a) and Wilcoxon-rank sum test (b)