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Table 5 Summarized of treatment regimens and outcome of vitamin D supplementation

From: Relationship between vitamin D and chronic spontaneous urticaria: a systematic review

N Sindher et al. [27]** Rorie et al. [26]†† Rasool et al. [25]§§ Oguz Topal et al. [24] Boonpiyathad et al. [31] Ariaee et al. [19] Dabas et al. [32]
1 21 21 48 57 57 50 20 200
Intervention Vitamin D3
400 IU/day
Vitamin D3
2000 IU/day
Vitamin D3
4000 IU/day
Vitamin D3
600 IU/day
Vitamin D3
60,000 IU/week
Vitamin D3 60,000 IU/week,
4 weeks
Hydroxyzine
25 mg/day, 6 weeks
Corticosteroid
6 mg/day, 6 weeks
Vitamin D3
300,000 IU/month
Vitamin D2
20,000 IU/day
Vitamin D
(unknown form)
50,000 unit/week
Vitamin D (unknown form)
Group A
Vitamin D 2000 IU/day
Group B
Vitamin D 60,000 IU/week
Group C
None
Duration 8 weeks ND 12 weeks 12 weeks 4 weeks 4 weeks 12 weeks 6 weeks 8 weeks 12 weeks
Vitamin D status (ng/mL)
Before treatment 4.7 ND 28.8 ± 2.2 37.1 ± 3.4 16.98 ± 1.43 18.95 ± 1.42 ND 13 (8–29)
median (min–max)
ND ND
End of treatment ND 65 56.0 ± 3.9 35.8 ± 2.3 56.74 ± 3.76
(p < 0 .0001)
41.73 ± 2.85
(p < 0.0001)
ND 40 (28–62)
median (min–max)
ND ND
Outcome Continued to have intermittent urticaria Complete resolution without antihistamine Decrease total USS scores
(mean ± SE)
VAS score
(mean ± SEM)
UAS4
(median(min–max))
UAS7 USS
(mean ± SD)
UAS4 (mean)
15.0 ± 2.9
(p = 0.02)
24.1 ± 4.0 Before After Before After Before After Before After Before After Before After 6 weeks After 12 weeks
6.7 ± 0.04 5.2 ± 0.70
p = 0.009
6.68 ± 0.40 1.86 ± 0.39
p < 0.0001
21
(0–42.0)
6
(0–21.0)
p < 0.001
27
(6–38)
15
(2–33)
235 ± 13.9 11.2 ± 9.6 GroupA
11.8 ± 7.6 6.6 ± 6.0 5.3 ± 5.2
5-D itch score
(mean)
CU-Q2oL
(median(min–max))
DLQI scores DLQI scores
(mean ± SD)
Group B
Before After Before After Before After Before After Before After 13.0 ± 8.0 6.4 ± 5.0 4.2 ± 3.5
14.5 ± 0.72 12.06 ± 1.10
p = 0.007
13.9 ± 0.68 5.01 ± 0.94
p < 0.0001
38 (6.5–115.2) 10.8
(0–43.4)
p < 0.001
13
(4–31)
6
(1–20)
10.8 ± 1.6 0.9 ± 4.8 Group C
12.9 ± 7.03 8.0 ± 5.7 6.1 ± 4.8
  1. 5-D itch score, 5-dimension itch score; CU-Q2oL, Chronic Urticaria Quality of Life Questionnaire; DLQI, Dermatology Life Quality Index; ND, not defined; UAS, urticaria activity score; USS score, the Urticaria Symptom Severity Score; VAS, visual analogue scale
  2. **CSU patients in Sindher et al. was treated with low dose vitamin D3 without response, then the patient was treated with higher dosage of vitamin D3 [26]
  3. ††CSU patients in Rorie et al. were randomized to vitamin D3 4000 IU/day or 600 IU/day [25]
  4. §§CSU patients in Rasool et al. were randomized to vitamin D3 60,0000 IU/week alone or vitamin D3 60,000 IU/week and hydroxyzine 25 mg/day and corticosteroid 6 mg/day [24]