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Table 3 Comparison of reported degree severity of serum vitamin D levels in CSU patients and controls

From: Relationship between vitamin D and chronic spontaneous urticaria: a systematic review

Studies Thorp et al. [28] Chandrashekar et al. [20] Grzanka et al. [21] Movahedi et al. [23] Woo et al. [29]
Cases Allergic rhinitis
controls
Cases Healthy controls Cases Healthy
controls
Cases Healthy controls Cases Healthy controls
N 25 25 45 45 35 33 114 187 72 72
Vitamin D levels 29.4
(mean)
39.6
(mean)
12.7 ± 2.7 24.3 ± 13.5 26.0
(median)
31.1
(median)
15.8 22.6 11.86
(mean)
20.77
(mean)
Sufficiency ND ND ND 11/45
(24.44%)
ND ND 10
(8.8%)
49
(26.2%)
2
(2%)
15
(20%)
Insufficiency ND ND ND 18/45
(40%)
11
(31.4%)
13
(39.4%)
18*
(15.8%)
31
(16.6%)
7
(10%)
20
(27%)
Deficiency 12
(48%)
7
(28%)
ND 16/45
(35.55%)
11*
(31.4%)
2
(6%)
86
(75.4%)
107
(57.2%)
28
(39%)
32
(45%)
Severe deficiency ND ND ND ND 1
(2.9%)
0
(0%)
ND ND 35*
(49%)
5
(8%)
Definition
 Sufficiency ND > 30 ng/mL ≥ 30 ng/mL ND ≥ 30 ng/mL
 Insufficiency ND Between 20 and 30 ng/mL 20–< 30 ng/mL 20–30 ng/mL Between 20 and 29 ng/mL
 Deficiency < 30 ng/mL < 20 ng/mL < 20 ng/mL < 20 ng/mL < 20 ng/mL
 Critically low/Severe deficiency ND ND < 10 ng/mL ND < 10 ng/mL
Studies Rasool et al. [25] Boonpiyathad et al. [31] Oguz Topal et al. [24] Nasiri-Kalmarzi et al. [14] Rather et al. [33]
Cases Healthy
controls
Cases Healthy controls Cases Healthy controls Case Healthy controls Case Controls
N 147 130 60 40 58 45 110 110 110 110
Vitamin D levels 17.87
(mean)
27.65
(mean)
15.0
(median)
30.0
(median)
8.45
(median)
15.3
(median)
19.26 ± 1.26
(mean)
31.72 ± 7.14
(mean)
19.6 ± 6.9
(mean)
38.5 ± 6.7
(mean)
Sufficiency ND ND ND ND ND ND ND ND 23
(20.91%)
71
(64.54%)
Insufficiency 91.3% 63.84% 28% 45% 57*
(98.3%)
39
(86.7%)
58.02% 48.89% 17
(15.45%)
24
(21.82%)
Deficiency 55%* 0% 52*
(89.7%)
31
(68.9%)
70
(63.64%)
15
(13.64%)
Severe deficiency ND ND ND ND ND ND ND ND ND ND
Definition
 Sufficiency > 30 ng/mL ND > 30 µg/L ND > 30 ng/mL
 Insufficiency 20–30 ng/mL > 20–< 30 ng/mL < 30 µg/L ND 20–30 ng/mL
 Deficiency 10–< 20 ng/mL < 20 ng/mL < 20 µg/L ND < 20 ng/mL
 Critically low/Severe deficiency < 10 ng/mL ND ND ND ND
  1. CSU, chronic spontaneous urticaria; ND, not defined
  2. * Significant difference compared to the control group