Table 3 Comparison of reported degree severity of serum vitamin D levels in CSU patients and controls
From: Relationship between vitamin D and chronic spontaneous urticaria: a systematic review
Studies | Thorp et al. [28] | Chandrashekar et al. [20] | Grzanka et al. [21] | Movahedi et al. [23] | Woo et al. [29] | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Allergic rhinitis controls | Cases | Healthy controls | Cases | Healthy controls | Cases | Healthy controls | Cases | Healthy controls | |
N | 25 | 25 | 45 | 45 | 35 | 33 | 114 | 187 | 72 | 72 |
Vitamin D levels | 29.4 (mean) | 39.6 (mean) | 12.7 ± 2.7 | 24.3 ± 13.5 | 26.0 (median) | 31.1 (median) | 15.8 | 22.6 | 11.86 (mean) | 20.77 (mean) |
Sufficiency | ND | ND | ND | 11/45 (24.44%) | ND | ND | 10 (8.8%) | 49 (26.2%) | 2 (2%) | 15 (20%) |
Insufficiency | ND | ND | ND | 18/45 (40%) | 11 (31.4%) | 13 (39.4%) | 18* (15.8%) | 31 (16.6%) | 7 (10%) | 20 (27%) |
Deficiency | 12 (48%) | 7 (28%) | ND | 16/45 (35.55%) | 11* (31.4%) | 2 (6%) | 86 (75.4%) | 107 (57.2%) | 28 (39%) | 32 (45%) |
Severe deficiency | ND | ND | ND | ND | 1 (2.9%) | 0 (0%) | ND | ND | 35* (49%) | 5 (8%) |
Definition | ||||||||||
 Sufficiency | ND | > 30 ng/mL | ≥ 30 ng/mL | ND | ≥ 30 ng/mL | |||||
 Insufficiency | ND | Between 20 and 30 ng/mL | 20–< 30 ng/mL | 20–30 ng/mL | Between 20 and 29 ng/mL | |||||
 Deficiency | < 30 ng/mL | < 20 ng/mL | < 20 ng/mL | < 20 ng/mL | < 20 ng/mL | |||||
 Critically low/Severe deficiency | ND | ND | < 10 ng/mL | ND | < 10 ng/mL | |||||
Studies | Rasool et al. [25] | Boonpiyathad et al. [31] | Oguz Topal et al. [24] | Nasiri-Kalmarzi et al. [14] | Rather et al. [33] | |||||
|---|---|---|---|---|---|---|---|---|---|---|
Cases | Healthy controls | Cases | Healthy controls | Cases | Healthy controls | Case | Healthy controls | Case | Controls | |
N | 147 | 130 | 60 | 40 | 58 | 45 | 110 | 110 | 110 | 110 |
Vitamin D levels | 17.87 (mean) | 27.65 (mean) | 15.0 (median) | 30.0 (median) | 8.45 (median) | 15.3 (median) | 19.26 ± 1.26 (mean) | 31.72 ± 7.14 (mean) | 19.6 ± 6.9 (mean) | 38.5 ± 6.7 (mean) |
Sufficiency | ND | ND | ND | ND | ND | ND | ND | ND | 23 (20.91%) | 71 (64.54%) |
Insufficiency | 91.3% | 63.84% | 28% | 45% | 57* (98.3%) | 39 (86.7%) | 58.02% | 48.89% | 17 (15.45%) | 24 (21.82%) |
Deficiency | 55%* | 0% | 52* (89.7%) | 31 (68.9%) | 70 (63.64%) | 15 (13.64%) | ||||
Severe deficiency | ND | ND | ND | ND | ND | ND | ND | ND | ND | ND |
Definition | ||||||||||
 Sufficiency | > 30 ng/mL | ND | > 30 µg/L | ND | > 30 ng/mL | |||||
 Insufficiency | 20–30 ng/mL | > 20–< 30 ng/mL | < 30 µg/L | ND | 20–30 ng/mL | |||||
 Deficiency | 10–< 20 ng/mL | < 20 ng/mL | < 20 µg/L | ND | < 20 ng/mL | |||||
 Critically low/Severe deficiency | < 10 ng/mL | ND | ND | ND | ND | |||||