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Table 3 Analytical and functional respiratory tests according to alpha 1 antitrypsin genotype

From: Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

  PI*MM (n = 503) PI*MS (n = 110) PI*MZ (n = 15) PI*SS (n = 14) PI*SZ (n = 6) P value*
FEV1 (l) 0.23
 Median (IQ25–75) 2.9 (2.5–3.4) 2.9 (2.4–3.4) 2.9 (2.7–3.3) 3.1 (2.8–3.7) 3.3 (3.2–3.3)
FEV1 (%) 0.0763
 Median (IQ25–75) 90 (81–100) 91 (76–101) 92 (84–105) 97 (86–99) 101 (99–111)
Total IgE (IU/dL)§ 0.194
 Median (IQ25–75) 272 (124–576) 207 (74–538) 165 (115–399) 151 (127–646) 169 (90–582)
IgE Dermatophagoides pteronyssinus 0.372
 Median (IQ25–75) 45 (17–100) 31 (9–101) 70 (11–101) 34 (20–89) 61 (30–101)
IgE Dermatophagoides farinae 0.273
 Median (IQ25–75) 29 (12–80) 17 (6.6–54) 41 (14–79) 24 (8.8–74) 31 (21–84)
IgE Blomia tropicalis 0.89
 Median (IQ25–75) 7 (2.1–22) 8 (2.5–19) 6 (5.2–9.6) 9.5 (2–18) 4.5 (1–8.5)
IgE Lepidoglyphus destructor 0.348
 Median (IQ25–75) 2 (1–6) 3.1 (1.1–8) 4 (3.6–10) 4 (2–8) 2.2 (2–16)
IgE Tyrophagus putrescientae 0.409
 Median (IQ25–75) 2.3 (1–8) 2.3 (1.4–5) 1 (1–1.01) 1.6 (0.7–8) 2.1
IgE Acarus siro 0.129
 Median (IQ25–75) 2 (0.9–7) 4 (3–5) 10 (4.3–35) 5.5 (1–11) 23.3
IgA (mg/dL)§ 0.333
 Median (IQ25–75) 216.5 (164–285) 204 (150.8–261) 261 (181–331) 224 (193–238) 255 (160–267)
Eosinophils (109/L)§ 0.0228
 Median(IQ25–75) 0.3 (0.2–0.5) 0.3 (0.2–0.4) 0.4 (0.3–0.6) 0.5 (0.3–0.6) 0.3 (0.2–0.4)
Nasal cytology eosinophils (%) 0.378
 Median (IQ25–75) 40 (10–70) 20 (7.5–60) 45 (33–65) 50 (30–65) 50
AAT (mg/dL)§ 1.18e−25
 Median (IQ25–75) 138 (123–159) 116 (104–137) 80 (78–87) 89 (86–96) 64 (61.3–70.5)
  1. FEV1 (forced expiratory volume in the 1 s), IgE (immunoglobulin E), IgA (immunoglobulin A), AAT (alpha1 antitrypsin)
  2. * Kruskal–Wallis statistic analysis
  3. Statistical significance, p value < 0.05
  4. §Normal value IgE: 10–179 IU/ml; Normal value of IgA: 80–310 mg/dl; Normal value of blood eosinophils: 0–0.54 × 109/L; Normal value ATT: 100–200 mg/dL (1.0–2.0 g/L)