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Table 1 Demographic, clinical and analytical features of the studied population

From: Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

  Global (n = 648) Intermittent (n = 253) Mild (n = 246) Moderate (n = 101) Severe (n = 48) P value*
Sex, n (%) 0.316
 Male 233 (34) 90 (36) 84 (34) 38 (38) 11 (23)
 Female 425 (66) 163 (64) 162 (66) 62 (62) 37 (77)
Age, years 1.72e−12
 Median (IQ25–75) 29 (20–38) 27 (20–36) 27 (19–35) 34 (24–44) 41 (34–53)
Smoker n (%) 54 (8) 24 (9.5) 21 (8.5) 9 (9) 0 0.369
Obesity n (%) 115 (18) 46 (18.2) 36 (14.9) 19 (19.2) 13 (27) 0.221
Conjunctivitis n (%) 107 (16.5) 54 (21.3) 40 (16.3) 11 (11) 2 (4.2) 0.008201
Rhinitis n (%) 640 (98.8) 250 (98.8) 244 (99.2) 99 (99) 47 (97.9) 0.885
Polyposis n (%) 17 (2.62) 1 (0.8) 2 (0.8) 9 (9) 4 (8.3) 0.00013
Chronic sinusitis n (%) 32 (4.94) 11 (4.3) 11 (4.5) 8 (8) 2 (4.2) 0.519
Atopic dermatitis n (%) 23 (3.55) 12 (4.7) 5 (2) 5 (5) 1 (2.1) 0.295
Previous pneumonia n (%) 5 (0.77) 1 (0.4) 2 (0.8) 1 (1) 1 (2.1) 0.332
FEV1 (l) 3.98e−22
 Median (IQ25–75) 2.9 (2.5–3.4) 3.1 (2.7–3.6) 2.9 (2.6–3.5) 2.6 (2.2–3.1) 2.0 (1.7–2.5)
FEV1 (%) 1.14e−24
 Median (IQ25–75) 90 (81–100) 95 (88–104) 90.5 (84–98) 78 (68–90) 74 (60–81)
Feno (ppb) 0.873
 Median (IQ25–75) 40 (23–72) 41 (23–73) 41 (26–72) 35.5 (19–69) 38 (21–60)
Total IgE (IU/ml)§ 0.0789
 Median (IQ25–75) 255 (117–563) 225 (111.5–533) 274 (113–615) 305 (124–711) 213 (93–426)
IgE Dermatophagoides pteronyssinus 0.0637
 Median (IQ25–75) 42 (15–100) 34 (13–99) 51 (21–101) 44 (16–100) 42 (5.8–98)
IgE Dermatophagoides farinae 0.119
 Median (IQ25–75) 27 (11–79) 21 (10–66) 34 (12–81) 26 (11–85) 32 (5.7–78.8)
IgE Blomia tropicalis 0.931
 Median (IQ25–75) 7 (2.1–21) 7 (2–19) 6.8 (3–23) 8.8 (2.1–20) 6.9 (3–19)
IgE Lepidoglyphus destructor 0.448
 Median (IQ25–75) 2.4 (1–7) 2.6 (0.9–6) 2.1 (1–6) 2.1 (1–11) 4.1 (2–9)
IgE Tyrophagus putrescientae 0.743
 Median (IQ25–75) 2 (1–7.5) 3 (1–7) 2 (1–7) 2 (1–8.5) 3.1 (1–1.9)
IgE Acarus siro 0.389
 Median (IQ25–75) 2.6 (1–7) 2.7 (0.9–7.5) 2.4 (1–7) 5 (1–9) 1.3 (0.7–1.8)
IgA (mg/dL)§ 0.00024
 Median (IQ25–75) 217 (162–279) 220.5 (164–292) 205.5 (157–260) 205.5 (161–271.5) 268 (220–334)
Eosinophils (109/L)§ 0.153
 Median (IQ25–75) 0.3 (0.2–0.5) 0.3 (0.2–0.5) 0.3 (0.2–0.5) 0.3 (0.2–0.5) 0.3 (0.1–0.5)
Nasal cytology eosinophils (%) 0.265
 Median (IQ25–75) 37.5 (10–70) 40 (10–70) 40 (15–70) 30 (5–50) 40 (5–60)
AAT (mg/dL)§ 0.945
 Median(IQ25–75) 134 (118–154) 135 (115–159) 134 (118–154) 133 (116–149) 135 (119–144)
  1. FEV1 (forced expiratory volume in the 1 s), FENO (fractional exhaled nitric oxide), IgE (immunoglobulin E), IgA (immunoglobulin A), AAT (alpha1 antitrypsin)
  2. * Kruskal–Wallis statistic analysis for continuous non normal variables and Chi square or F-test for nominal ones
  3. Statistical significance, p value < 0.01
  4. §Normal value IgE: 10–179 IU/ml; Normal value of IgA: 80–310 mg/dl; Normal value of blood eosinophils: 0–0.54 × 109/L; Normal value ATT: 100–200 mg/dL (1.0–2.0 g/L)