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Table 1 Demographic, clinical and analytical features of the studied population

From: Alpha 1 antitrypsin distribution in an allergic asthmatic population sensitized to house dust mites

 

Global (n = 648)

Intermittent (n = 253)

Mild (n = 246)

Moderate (n = 101)

Severe (n = 48)

P value*

Sex, n (%)

0.316

 Male

233 (34)

90 (36)

84 (34)

38 (38)

11 (23)

 Female

425 (66)

163 (64)

162 (66)

62 (62)

37 (77)

Age, years

1.72e−12‡

 Median (IQ25–75)

29 (20–38)

27 (20–36)

27 (19–35)

34 (24–44)

41 (34–53)

Smoker n (%)

54 (8)

24 (9.5)

21 (8.5)

9 (9)

0

0.369

Obesity n (%)

115 (18)

46 (18.2)

36 (14.9)

19 (19.2)

13 (27)

0.221

Conjunctivitis n (%)

107 (16.5)

54 (21.3)

40 (16.3)

11 (11)

2 (4.2)

0.008201‡

Rhinitis n (%)

640 (98.8)

250 (98.8)

244 (99.2)

99 (99)

47 (97.9)

0.885

Polyposis n (%)

17 (2.62)

1 (0.8)

2 (0.8)

9 (9)

4 (8.3)

0.00013‡

Chronic sinusitis n (%)

32 (4.94)

11 (4.3)

11 (4.5)

8 (8)

2 (4.2)

0.519

Atopic dermatitis n (%)

23 (3.55)

12 (4.7)

5 (2)

5 (5)

1 (2.1)

0.295

Previous pneumonia n (%)

5 (0.77)

1 (0.4)

2 (0.8)

1 (1)

1 (2.1)

0.332

FEV1 (l)

3.98e−22‡

 Median (IQ25–75)

2.9 (2.5–3.4)

3.1 (2.7–3.6)

2.9 (2.6–3.5)

2.6 (2.2–3.1)

2.0 (1.7–2.5)

FEV1 (%)

1.14e−24‡

 Median (IQ25–75)

90 (81–100)

95 (88–104)

90.5 (84–98)

78 (68–90)

74 (60–81)

Feno (ppb)

0.873

 Median (IQ25–75)

40 (23–72)

41 (23–73)

41 (26–72)

35.5 (19–69)

38 (21–60)

Total IgE (IU/ml)§

0.0789

 Median (IQ25–75)

255 (117–563)

225 (111.5–533)

274 (113–615)

305 (124–711)

213 (93–426)

IgE Dermatophagoides pteronyssinus

0.0637

 Median (IQ25–75)

42 (15–100)

34 (13–99)

51 (21–101)

44 (16–100)

42 (5.8–98)

IgE Dermatophagoides farinae

0.119

 Median (IQ25–75)

27 (11–79)

21 (10–66)

34 (12–81)

26 (11–85)

32 (5.7–78.8)

IgE Blomia tropicalis

0.931

 Median (IQ25–75)

7 (2.1–21)

7 (2–19)

6.8 (3–23)

8.8 (2.1–20)

6.9 (3–19)

IgE Lepidoglyphus destructor

0.448

 Median (IQ25–75)

2.4 (1–7)

2.6 (0.9–6)

2.1 (1–6)

2.1 (1–11)

4.1 (2–9)

IgE Tyrophagus putrescientae

0.743

 Median (IQ25–75)

2 (1–7.5)

3 (1–7)

2 (1–7)

2 (1–8.5)

3.1 (1–1.9)

IgE Acarus siro

0.389

 Median (IQ25–75)

2.6 (1–7)

2.7 (0.9–7.5)

2.4 (1–7)

5 (1–9)

1.3 (0.7–1.8)

IgA (mg/dL)§

0.00024‡

 Median (IQ25–75)

217 (162–279)

220.5 (164–292)

205.5 (157–260)

205.5 (161–271.5)

268 (220–334)

Eosinophils (109/L)§

0.153

 Median (IQ25–75)

0.3 (0.2–0.5)

0.3 (0.2–0.5)

0.3 (0.2–0.5)

0.3 (0.2–0.5)

0.3 (0.1–0.5)

Nasal cytology eosinophils (%)

0.265

 Median (IQ25–75)

37.5 (10–70)

40 (10–70)

40 (15–70)

30 (5–50)

40 (5–60)

AAT (mg/dL)§

0.945

 Median(IQ25–75)

134 (118–154)

135 (115–159)

134 (118–154)

133 (116–149)

135 (119–144)

  1. FEV1 (forced expiratory volume in the 1 s), FENO (fractional exhaled nitric oxide), IgE (immunoglobulin E), IgA (immunoglobulin A), AAT (alpha1 antitrypsin)
  2. * Kruskal–Wallis statistic analysis for continuous non normal variables and Chi square or F-test for nominal ones
  3. ‡Statistical significance, p value < 0.01
  4. §Normal value IgE: 10–179 IU/ml; Normal value of IgA: 80–310 mg/dl; Normal value of blood eosinophils: 0–0.54 × 109/L; Normal value ATT: 100–200 mg/dL (1.0–2.0 g/L)
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Clinical and Translational Allergy

ISSN: 2045-7022

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