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Table 3 Plasma metabolites discriminating CM-FPIES versus IgE-CMA patients

From: Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow’s milk

Metabolites

p value

(FPIES vs IgE)*

Formula

Mass

Chemical class

Kegg number

RT ZIC-pHILIC (min)

RT C18 (min)

Identification level

Arginine

0.0496

C6H14N4O2

174.1117

Amino acids, peptides and analogues

C00062

–

0.78

1

Serine

0.0156

C3H7NO3

105.0426

C00065

–

0.83

1

N-Acetyl-DL-tryptophan

0.0256

C13H14N2O3

246.1004

NA

–

6.20

1

l-Cysteine S-sulphate

0.0496

C3H7NO5S2

200.9766

C05824

10.14

–

1

Alpha-d-Aminoadipic acid

0.0496

C6H11NO4

161.0688

C00956

9.21

–

1

Threonine/l-homoserine/d-allo-threonine

0.0386

C4H9NO3

119.0582

C00188/C00263/C05519

7.37

–

3

Methionine

0.0516

C5H11NO2S

149.0511

C00073

–

1.05

1

Phenylalanine

0.0516

C9H11NO2

165.0790

C00079

–

2.09

1

N-Isovaleroylglycine/N-acetyl-DL-valine/N-acetyl-DL-norvaline

0.0987

C7H13NO3

159.0895

 

2.19

–

3

Betaine/valine

0.0591

C5H11NO2

117.0790

C00719/C00183

5.19

–

1

Nicotinamide

0.0048

C6H6N2O

122.0480

Aromatic heteromonocyclic compounds

C00153

–

1.00

1

Theobromine

0.0360

C7H8N4O2

180.0647

C07480

–

2.38

1

Folic acid

0.0048

C19H19N7O6

441.1397

C00504

–

4.64

1

Uric acid

0.0673

C5H4N4O3

168.0283

C00366

–

0.94

1

Hypoxanthine

0.0663

C5H4N4O

136.0385

C00262

–

0.99

1

Riboflavin

0.0872

C17H20N4O6

376.1383

C00255

–

5.18

1

3-Hydroxydecanoic acid/10-hydroxydecanoic acid

0.0447

C10H20O3

188.1412

Organic acids and derivatives

C02774

1.42

–

3

2-Hydroxycaproic acid

0.0591

C6H12O3

132.0786

NA

2.11

–

1

d-Galacturonic acid

0.0390

C6H10O7

194.0426

Carbohydrates and carbohydrate conjugates

C08348

9.37

–

1

l-Arabitol/adonitol/d-arabitol

0.0673

C5H12O5

152.0685

C00532/C00474/C01904

6.40

–

1

Myristic acid

0.0496

C14H28O2

228.2089

Lipids

C06424

1.36

–

1

DL-Alpha-hydroxystearic acid

0.0256

C18H36O3

300.2664

NA

1.34

–

1

Methyl fatty acid

0.0016

C15H30O2

242.2246

NA

1.35

–

3

C18:0-FA

0.0214

C18H36O2

284.2715

NA

1.34

–

3

Palmitic acid

0.0663

C16H32O2

256.2402

C00249

1.35

–

1

  1. p < 0.05 values are shown in italic
  2. The discriminant metabolites were identified using nonparametric Mann–Whitney test. The metabolites were considered as discriminant when p value < 0.1
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Clinical and Translational Allergy

ISSN: 2045-7022

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