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Table 3 Plasma metabolites discriminating CM-FPIES versus IgE-CMA patients

From: Deep analysis of immune response and metabolic signature in children with food protein induced enterocolitis to cow’s milk

Metabolites p value
(FPIES vs IgE)*
Formula Mass Chemical class Kegg number RT ZIC-pHILIC (min) RT C18 (min) Identification level
Arginine 0.0496 C6H14N4O2 174.1117 Amino acids, peptides and analogues C00062 0.78 1
Serine 0.0156 C3H7NO3 105.0426 C00065 0.83 1
N-Acetyl-DL-tryptophan 0.0256 C13H14N2O3 246.1004 NA 6.20 1
l-Cysteine S-sulphate 0.0496 C3H7NO5S2 200.9766 C05824 10.14 1
Alpha-d-Aminoadipic acid 0.0496 C6H11NO4 161.0688 C00956 9.21 1
Threonine/l-homoserine/d-allo-threonine 0.0386 C4H9NO3 119.0582 C00188/C00263/C05519 7.37 3
Methionine 0.0516 C5H11NO2S 149.0511 C00073 1.05 1
Phenylalanine 0.0516 C9H11NO2 165.0790 C00079 2.09 1
N-Isovaleroylglycine/N-acetyl-DL-valine/N-acetyl-DL-norvaline 0.0987 C7H13NO3 159.0895   2.19 3
Betaine/valine 0.0591 C5H11NO2 117.0790 C00719/C00183 5.19 1
Nicotinamide 0.0048 C6H6N2O 122.0480 Aromatic heteromonocyclic compounds C00153 1.00 1
Theobromine 0.0360 C7H8N4O2 180.0647 C07480 2.38 1
Folic acid 0.0048 C19H19N7O6 441.1397 C00504 4.64 1
Uric acid 0.0673 C5H4N4O3 168.0283 C00366 0.94 1
Hypoxanthine 0.0663 C5H4N4O 136.0385 C00262 0.99 1
Riboflavin 0.0872 C17H20N4O6 376.1383 C00255 5.18 1
3-Hydroxydecanoic acid/10-hydroxydecanoic acid 0.0447 C10H20O3 188.1412 Organic acids and derivatives C02774 1.42 3
2-Hydroxycaproic acid 0.0591 C6H12O3 132.0786 NA 2.11 1
d-Galacturonic acid 0.0390 C6H10O7 194.0426 Carbohydrates and carbohydrate conjugates C08348 9.37 1
l-Arabitol/adonitol/d-arabitol 0.0673 C5H12O5 152.0685 C00532/C00474/C01904 6.40 1
Myristic acid 0.0496 C14H28O2 228.2089 Lipids C06424 1.36 1
DL-Alpha-hydroxystearic acid 0.0256 C18H36O3 300.2664 NA 1.34 1
Methyl fatty acid 0.0016 C15H30O2 242.2246 NA 1.35 3
C18:0-FA 0.0214 C18H36O2 284.2715 NA 1.34 3
Palmitic acid 0.0663 C16H32O2 256.2402 C00249 1.35 1
  1. p < 0.05 values are shown in italic
  2. The discriminant metabolites were identified using nonparametric Mann–Whitney test. The metabolites were considered as discriminant when p value < 0.1