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Table 1 In vitro medication delivery through the test VHC with small/medium face masks at different flow rates and holding times

From: 5th Pediatric Allergy and Asthma Meeting (PAAM)

Flow rate and corresponding age Mask Holding time, s Mean medication delivery through test VHC, μg/dose Body weight 50th percentile, kg Medication delivered per dose, ng/kg*
4.9 L/min (6–12 months) Small 0 0.85 (± 0.04) 7.5–9.9 86–113
2 0.86 (± 0.14) 87–115
5 0.55 (± 0.16) 56–73
10 0.62 (± 0.02) 63–83
8.0 L/min (2–5 years) Medium 0 0.74 (± 0.05) 12.3–18.0 41–60
2 0.93 (± 0.05) 52–76
5 0.72 (± 0.07) 40–59
10 0.57 (± 0.05) 32–46
12.0 L/min (> 5 years) Medium 0 1.16 (± 0.07) 18.0 64
2 0.96 (± 0) 53
5 0.78 (± 0.18) 43
10 0.61 (± 0.02) 34
  1. Data corresponding to age group 13–23 months are not available
  2. *Inhalation of 2.5 µg tiotropium Respimat® (as two actuations) in a 70 kg adult without use of the test VHC and face mask delivers approximately 2.5 μg or 36 ng/kg