Table 1 In vitro medication delivery through the test VHC with small/medium face masks at different flow rates and holding times
Flow rate and corresponding age | Mask | Holding time, s | Mean medication delivery through test VHC, μg/dose | Body weight 50th percentile, kg | Medication delivered per dose, ng/kg* |
|---|---|---|---|---|---|
4.9 L/min (6–12 months) | Small | 0 | 0.85 (± 0.04) | 7.5–9.9 | 86–113 |
2 | 0.86 (± 0.14) | 87–115 | |||
5 | 0.55 (± 0.16) | 56–73 | |||
10 | 0.62 (± 0.02) | 63–83 | |||
8.0 L/min (2–5 years) | Medium | 0 | 0.74 (± 0.05) | 12.3–18.0 | 41–60 |
2 | 0.93 (± 0.05) | 52–76 | |||
5 | 0.72 (± 0.07) | 40–59 | |||
10 | 0.57 (± 0.05) | 32–46 | |||
12.0 L/min (> 5 years) | Medium | 0 | 1.16 (± 0.07) | 18.0 | 64 |
2 | 0.96 (± 0) | 53 | |||
5 | 0.78 (± 0.18) | 43 | |||
10 | 0.61 (± 0.02) | 34 |