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Table 3 Distribution and comparisons of the asthma-related outcomes among asthma phenotypes, stratified by age

From: Having concomitant asthma phenotypes is common and independently relates to poor lung function in NHANES 2007–2012

 

Total

n (wt%)

Asthma attack

Asthma-related ED

≥ 2 asthma symptoms

Work/school absenteeism

Asthma medication

Lung function

≥ 1 reliever medication

≥ 2 controller medication

FEV1 < LLN

FEV1% predicted§

FEV1/FVC < LLN

< 40 yrs

 1 phenotype

118 (56)

85 (70)

27 (20)

59 (56)

15 (21)

55 (43)

17 (11)

10 (7)

95.6

(90.2–102.1)

26 (20)

 2 phenotypes

97 (40)

69 (75)

26 (32)

57 (73)

12 (9)

41 (40)

8 (9)

19 (23)

91.8

(81.3–99.2)

25 (29)

 3 phenotypes

12 (4)

10 (73)

5 (40)

8 (72)

4 (25)

9 (68)

1 (4)

3 (36)

81.9

(75.3–84.6)

4 (29)

 p value*

  1 versus 2

 

0.43

0.10

0.052

0.04

0.72

0.64

0.006

0.07

0.25

  2 versus 3

 

0.92

0.55

0.96

0.07

0.15

0.46

0.43

0.009

0.98

  1 versus 3

 

0.86

0.11

0.39

0.73

0.20

0.34

0.01

< 0.001

0.48

≥ 40 yrs

 1 phenotype

153 (46)

104 (65)

35 (23)

76 (62)

20 (15)

58 (33)

26 (17)

29 (20)

91.2

(81.6–99.2)

34 (26)

 2 phenotypes

136 (41)

92 (69)

28 (21)

70 (55)

12 (9)

60 (46)

43 (36)

31 (37)

80.4

(70.0–91.7)

27 (32)

 ≥ 3 phenotypes

41 (13)

26 (72)

4 (9)

30 (70)

8 (40)

22 (60)

16 (40)

12 (46)

74.0

(63.0–85.8)

16 (53)

 p value*

  1 versus 2

 

0.56

0.82

0.38

0.41

0.12

0.02

0.01

0.007

0.46

  2 versus ≥ 3

 

0.80

0.27

0.30

0.002

0.24

0.67

0.47

0.22

0.09

  1 versus ≥ 3

 

0.50

0.21

0.54

0.03

0.053

0.02

0.01

0.006

0.02

  1. Data presented as absolute numbers and proportions weighted for the U.S. population. p values < 0.05 are presented in italic. The 77 subjects included in the “non-classified” group were considered as missing
  2. ED emergency-department, FEV 1 forced expiratory volume in 1 s, FEV 1 /FVC forced expiratory volume in 1 s and functional vital capacity ratio, LLN lower limit of normality, Q1 first quartile; Q3: third quartile
  3. * Chi square test or Mann–Whitney U-test was used
  4. Short-acting β2-agonist or/and anticholinergic
  5. §Presented as median (Q1–Q3)