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Table 4 Number of hospitalisations with an associated diagnosis of erythema multiforme (EM) and Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) per million sold packages of drug classes involved in adverse reactions; Mainland Portugal, 2010–2014 (n = 215 hospitalisations)

From: Stevens–Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database

Drug class EM (N = 90) SJS/TEN (N = 125)
Antibiotics (NPS = 37,311,945) 0.75 0.88
Antiviral drugs (NPS = 686,221) 1.46 8.74
Hormones and synthetic substitutes (NPS = 69,570,259) 0.08 0.10
Antineoplastic and immunosuppressive drugs (NPS = 1,787,045) 3.92 5.60
Agents primarily affecting blood constituents (NPS = 37,608,542) 0.11
Analgesics, antipyretics, and antirheumatics (NPS = 71,419,516) 0.12 0.10
Anticonvulsants (NPS = 16,305,856) 0.43 1.17
Psychotropic agents (NPS = 100,008,577) 0.01 0.03
Agents primarily affecting the cardiovascular system (NPS = 198,300,264) 0.01 0.01
Uric acid metabolism drugs (NPS = 5,007,028) 2.40 4.99
  1. NPS number of drug packages sold