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Table 4 Number of hospitalisations with an associated diagnosis of erythema multiforme (EM) and Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN) per million sold packages of drug classes involved in adverse reactions; Mainland Portugal, 2010–2014 (n = 215 hospitalisations)

From: Stevens–Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database

Drug class

EM (N = 90)

SJS/TEN (N = 125)

Antibiotics (NPS = 37,311,945)

0.75

0.88

Antiviral drugs (NPS = 686,221)

1.46

8.74

Hormones and synthetic substitutes (NPS = 69,570,259)

0.08

0.10

Antineoplastic and immunosuppressive drugs (NPS = 1,787,045)

3.92

5.60

Agents primarily affecting blood constituents (NPS = 37,608,542)

0.11

Analgesics, antipyretics, and antirheumatics (NPS = 71,419,516)

0.12

0.10

Anticonvulsants (NPS = 16,305,856)

0.43

1.17

Psychotropic agents (NPS = 100,008,577)

0.01

0.03

Agents primarily affecting the cardiovascular system (NPS = 198,300,264)

0.01

0.01

Uric acid metabolism drugs (NPS = 5,007,028)

2.40

4.99

  1. NPS number of drug packages sold