Stevens–Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database

Table 2 Results from binomial logistic regression with in-hospital mortality as the dependent variable

	Erythema multiforme		Stevens–Johnson syndrome/toxic epidermal necrolysis
	Crude OR (95% CI); P value	Adjusted OR (95% CI); P value^a	Crude OR (95% CI); P value	Adjusted OR (95% CI); P value^b
Male gender	7.5 (1.5–37.9); 0.015	23.9 (3.4–168.6); 0.001	1.4 (0.6–3.1); 0.432	–
Age	1.1^c (1.0–1.2); 0.011	1.1^c (1.0–1.2); 0.005	1.1^c (1.0–1.1); < 0.001	1.1^c (1.0–1.1); 0.002
Length of stay	1.0^d (0.9–1.1); 0.750	–	1.0^d (1.0–1.0); 0.398	–
Hypertension	2.9 (0.7–11.5); 0.129	0.7 (0.1–4.4); 0.721	0.9 (0.4–2.0); 0.729	–
Diabetes	1.6 (0.3–8.4); 0.571	–	1.7 (0.6–4.6); 0.316	–
Heart failure	1.4 (0.2–12.9); 0.742	–	4.6 (1.4–15.0); 0.011	4.1 (0.9–18.2); 0.060
Chronic kidney disease	2.9 (0.5–16.1); 0.213	–	2.5 (0.8–7.6); 0.117	0.7 (0.2–3.1); 0.725
Liver disease	^e	^e	3.7 (1.0–13.7); 0.051	7.9 (1.2–50.7); 0.031
HIV	^e	^e	0.6 (0.1–3.0); 0.562	–
Clinical entity
Stevens–Johnson syndrome	–	–	1.0^f	1.0^f
Stevens–Johnson syndrome–toxic epidermal necrolysis overlap	–	–	0.6 (0.1–3.1); 0.577	0.4 (0.1–3.4); 0.437
Toxic epidermal necrolysis	–	–	4.0 (1.7–9.5); 0.002	6.5 (2.3–18.8); 0.001

OR odds ratio, CI confidence interval
^aAdjusted for gender, age, and hypertension
^bAdjusted for age, Stevens–Johnson syndrome, toxic epidermal necrolysis, heart failure, chronic kidney disease, and liver disease
^cValues per year
^dValues per day
^eNo fatal cases were registered
^fReference category

ISSN: 2045-7022