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Table 1 Demographic and clinical characteristics of hospitalised patients with an associated diagnosis of erythema multiforme (EM) or Stevens–Johnson syndrome/toxic epidermal necrolysis (SJS/TEN); Mainland Portugal, 2009–2014 (n = 254 hospitalisations)

From: Stevens–Johnson syndrome/toxic epidermal necrolysis and erythema multiforme drug-related hospitalisations in a national administrative database

Characteristics Cutaneous adverse reactions SJS/TEN
EMa (N = 122) SJS/TEN (N = 132) P value Stevens–Johnson Syndrome (N = 73) SJS–TEN overlapb (N = 18) Toxic epidermal necrolysis (N = 41) P value
Episodes as main diagnosis—n (%) 34 (27.9) 89 (66.4)   45 (61.6) 14 (77.8) 30 (68.3)  
6-years incidence (per million inhabitants) 12.2 13.2   7.3 1.8 4.1  
Gender—n (%)
 Male 43 (35.2) 60 (45.5) 0.098 34 (46.6) 9 (50.0) 17 (41.5) 0.798
 Female 79 (64.8) 72 (54.5)   39 (53.4) 9 (50.0) 25 (58.5)  
Age (years)
 Median (percentile 25–75) 63 (44–77) 63 (45–75) 0.903 64 (46–79) 57 (34–72) 65 (48–74) 0.492
Comorbidities
 Hypertension 39 (32.0) 46 (34.8) 0.627 29 (39.7) 5 (27.8) 12 (29.3) 0.422
 Diabetes 19 (15.6) 22 (16.7) 0.813 13 (17.8) 4 (22.2) 5 (12.2) 0.589
 Heart failure 10 (8.2) 13 (9.8) 0.647 8 (11.0) 3 (16.7) 2 (4.9) 0.272
 Chronic kidney disease 12 (9.8) 15 (11.4) 0.693 7 (9.6) 4 (22.2) 4 (9.8) 0.340
 Liver disease 11 (9.0) 10 (7.6) 0.677 4 (5.5) 3 (16.7) 3 (7.3) 0.203
  Acute toxic hepatitis 7 (5.7) 6 (4.5) 0.882 2 (2.7) 2 (11.1) 2 (4.9) 0.269
 HIV 2 (1.6) 12 (9.1) 0.009 8 (11.0) 3 (16.7) 1 (2.4) 0.115
Length-of-stayc (days)
 Median (percentile 25–75) 10 (5–20) 15 (7–28) 0.007 15 (7–23) 23 (9–36) 14 (7–28) 0.456
In-hospital mortality—n (%) 9 (7.4) 32 (24.2) < 0.001 12 (16.4) 2 (11.1) 18 (43.9) 0.002
  1. aEncompasses 5 cases of EM minor, 11 cases of EM major, 10 cases of other forms of EM, and 96 cases of unspecified EM
  2. bStevens–Johnson and toxic epidermal necrolysis overlap syndrome
  3. cIncludes all episodes, including those resulting in the death of patients