From: Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil
Variables | Cohort as a whole (65 patients; 384 spirometry tests) Intercept (95% CI) | Slope (95% CI)a | p | Subgroup of patients receiving > 800 µg/day of ICS (22 patients; 57 spirometry tests) Intercept (95% CI) | Slope (95% CI)a | p |
---|---|---|---|---|---|---|
Pre-bronchodilator | ||||||
FVC (% predicted) | 90.87 (87.54; 94.20) | 0.09 (−0.05: 0.22) | 0.20 | 84.65 (76.69; 92.60) | 0.15 (−0.30; 0.60) | 0.50 |
FVC (z-score) | − 0.73 (− 1.01; − 0.45) | 0.00 (− 0.01; 0.01) | 0.70 | − 1.24 (− 1.92; − 0.55) | − 0.01 (− 0.05; 0.03) | 0.60 |
FEV1 (% predicted) | 81.24 (77.35; 85.13) | 0.20 (0.05; 0.34) | 0.01 | 77.07 (67.92; 86.22) | − 0.04 (− 0.60; 0.51) | 0.90 |
FEV1 (z-score) | − 1.22 (− 1.58; − 0.86) | 0.01 (− 0.01; 0.02) | 0.40 | − 1.80 (− 2.56; − 1.03) | − 0.01 (− 0.04; 0.03) | 0.80 |
FEV1/FVC ratio | 81.58 (79.31; 83.85) | 0.12 (0.04; 0.20) | 0.00 | 81.97 (75.49; 88.44) | − 0.11(− 0.39; 0.17) | 0.50 |
FEV1/FVC ratio (z-score) | − 0.89 (− 1.21; − 0.57) | 0.01 (0.00; 0.03) | 0.03 | − 1.15 (− 1.97; − 0.32) | 0.01 (− 0.03; 0.05) | 0.50 |
FEF25–75 % (% predicted) | 71.53 (65.48; 77.58) | 0.43 (0.20; 0.65) | 0.00 | 72.75 (55.33; 90.18) | − 0.24 (− 1.25; 0.76) | 0.60 |
FEF25–75 % (z-score) | − 1.43 (− 1.74; − 1.11) | − 0.02 (− 0.02; − 0.01) | 0.00 | − 2.02 (− 2.60; − 1.44) | − 0.02 (− 0.04; 0.00) | 0.03 |
Post-bronchodilator | ||||||
FVC (% predicted) | 93.96 (90.96; 96.96) | − 0.01 (− 0.16; 0.13) | 0.90 | 89.45 (81.62; 97.28) | − 0.07 (− 0.47; 0.33) | 0.70 |
FVC (z-score) | − 0.42 (− 0.71; − 0.13) | − 0.01 (− 0.02; 0.00) | 0.10 | − 0.89 (− 1.59; − 0.19) | − 0.02 (− 0.04; 0.01) | 0.30 |
FEV1 (% predicted) | 88.09 (84.61; 91.56) | 0.06 (− 0.06; 0.18) | 0.30 | 89.58 (80.62; 98.50) | − 0.48 (− 0.93; − 0.03) | 0.04 |
FEV1 (z-score) | − 0.79 (− 1.11; − 0.46) | 0.00 (− 0.01; 0.01) | 0.10 | − 1.38 (− 2.20; − 0.55) | − 0.01 (− 0.05; 0.03) | 0.70 |
FEV1/FVC ratio | 93.31 (90.75; 95.87) | 0.09 (− 0.04; 0.23) | 0.20 | 92.02 (85.11; 98.94) | 0.04 (− 0.21; 0.30) | 0.70 |
FEV1/FVC ratio (z-score) | − 0.44 (− 0.71; − 0.15) | 0.02 (0.00; 0.03) | 0.02 | − 0.45 (− 1.43; 0.52) | 0.01 (− 0.05; 0.07) | 0.70 |
FEF25–75 % (% predicted) | 90.60 (83.46; 97.75) | 0.11 (− 0.24; 0.46) | 0.50 | 87.98 (69.48; 106.47) | − 0.17 (− 1.12; 0.78) | 0.70 |
FEF25–75 % (z-score) | − 0.51 (− 0.87; − 0.16) | 0.01 (− 0.01; 0.02) | 0.30 | − 0.72 (− 1.64; 0.20) | − 0.01 (− 0.05; 0.04) | 0.80 |
Increase in FEV1 (%) | 9.48 (7.12; 11.84) | − 0.18 (− 0.32; − 0.03) | 0.02 | 12.07 (6.18; 17.97) | − 0.28 (− 0.67; 0.11) | 0.20 |