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Table 2 Longitudinal evaluation of spirometry tests, including pre-and post-bronchodilator values

From: Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil

Variables Cohort as a whole (65 patients; 384 spirometry tests) Intercept (95% CI) Slope (95% CI)a p Subgroup of patients receiving > 800 µg/day of ICS (22 patients; 57 spirometry tests)
Intercept (95% CI)
Slope (95% CI)a p
Pre-bronchodilator
 FVC (% predicted) 90.87 (87.54; 94.20) 0.09 (−0.05: 0.22) 0.20 84.65 (76.69; 92.60) 0.15 (−0.30; 0.60) 0.50
 FVC (z-score) − 0.73 (− 1.01; − 0.45) 0.00 (− 0.01; 0.01) 0.70 − 1.24 (− 1.92; − 0.55) − 0.01 (− 0.05; 0.03) 0.60
 FEV1 (% predicted) 81.24 (77.35; 85.13) 0.20 (0.05; 0.34) 0.01 77.07 (67.92; 86.22) − 0.04 (− 0.60; 0.51) 0.90
 FEV1 (z-score) − 1.22 (− 1.58; − 0.86) 0.01 (− 0.01; 0.02) 0.40 − 1.80 (− 2.56; − 1.03) − 0.01 (− 0.04; 0.03) 0.80
 FEV1/FVC ratio 81.58 (79.31; 83.85) 0.12 (0.04; 0.20) 0.00 81.97 (75.49; 88.44) − 0.11(− 0.39; 0.17) 0.50
 FEV1/FVC ratio (z-score) − 0.89 (− 1.21; − 0.57) 0.01 (0.00; 0.03) 0.03 − 1.15 (− 1.97; − 0.32) 0.01 (− 0.03; 0.05) 0.50
 FEF25–75 % (% predicted) 71.53 (65.48; 77.58) 0.43 (0.20; 0.65) 0.00 72.75 (55.33; 90.18) − 0.24 (− 1.25; 0.76) 0.60
 FEF25–75 % (z-score) − 1.43 (− 1.74; − 1.11) − 0.02 (− 0.02; − 0.01) 0.00 − 2.02 (− 2.60; − 1.44) − 0.02 (− 0.04; 0.00) 0.03
Post-bronchodilator
 FVC (% predicted) 93.96 (90.96; 96.96) − 0.01 (− 0.16; 0.13) 0.90 89.45 (81.62; 97.28) − 0.07 (− 0.47; 0.33) 0.70
 FVC (z-score) − 0.42 (− 0.71; − 0.13) − 0.01 (− 0.02; 0.00) 0.10 − 0.89 (− 1.59; − 0.19) − 0.02 (− 0.04; 0.01) 0.30
 FEV1 (% predicted) 88.09 (84.61; 91.56) 0.06 (− 0.06; 0.18) 0.30 89.58 (80.62; 98.50) − 0.48 (− 0.93; − 0.03) 0.04
 FEV1 (z-score) − 0.79 (− 1.11; − 0.46) 0.00 (− 0.01; 0.01) 0.10 − 1.38 (− 2.20; − 0.55) − 0.01 (− 0.05; 0.03) 0.70
 FEV1/FVC ratio 93.31 (90.75; 95.87) 0.09 (− 0.04; 0.23) 0.20 92.02 (85.11; 98.94) 0.04 (− 0.21; 0.30) 0.70
 FEV1/FVC ratio (z-score) − 0.44 (− 0.71; − 0.15) 0.02 (0.00; 0.03) 0.02 − 0.45 (− 1.43; 0.52) 0.01 (− 0.05; 0.07) 0.70
 FEF25–75 % (% predicted) 90.60 (83.46; 97.75) 0.11 (− 0.24; 0.46) 0.50 87.98 (69.48; 106.47) − 0.17 (− 1.12; 0.78) 0.70
 FEF25–75 % (z-score) − 0.51 (− 0.87; − 0.16) 0.01 (− 0.01; 0.02) 0.30 − 0.72 (− 1.64; 0.20) − 0.01 (− 0.05; 0.04) 0.80
 Increase in FEV1 (%) 9.48 (7.12; 11.84) − 0.18 (− 0.32; − 0.03) 0.02 12.07 (6.18; 17.97) − 0.28 (− 0.67; 0.11) 0.20
  1. aMonthly variation in response