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Table 2 Longitudinal evaluation of spirometry tests, including pre-and post-bronchodilator values

From: Lung function in severe pediatric asthma: a longitudinal study in children and adolescents in Brazil

Variables

Cohort as a whole (65 patients; 384 spirometry tests) Intercept (95% CI)

Slope (95% CI)a

p

Subgroup of patients receiving > 800 µg/day of ICS (22 patients; 57 spirometry tests)

Intercept (95% CI)

Slope (95% CI)a

p

Pre-bronchodilator

 FVC (% predicted)

90.87 (87.54; 94.20)

0.09 (−0.05: 0.22)

0.20

84.65 (76.69; 92.60)

0.15 (−0.30; 0.60)

0.50

 FVC (z-score)

− 0.73 (− 1.01; − 0.45)

0.00 (− 0.01; 0.01)

0.70

− 1.24 (− 1.92; − 0.55)

− 0.01 (− 0.05; 0.03)

0.60

 FEV1 (% predicted)

81.24 (77.35; 85.13)

0.20 (0.05; 0.34)

0.01

77.07 (67.92; 86.22)

− 0.04 (− 0.60; 0.51)

0.90

 FEV1 (z-score)

− 1.22 (− 1.58; − 0.86)

0.01 (− 0.01; 0.02)

0.40

− 1.80 (− 2.56; − 1.03)

− 0.01 (− 0.04; 0.03)

0.80

 FEV1/FVC ratio

81.58 (79.31; 83.85)

0.12 (0.04; 0.20)

0.00

81.97 (75.49; 88.44)

− 0.11(− 0.39; 0.17)

0.50

 FEV1/FVC ratio (z-score)

− 0.89 (− 1.21; − 0.57)

0.01 (0.00; 0.03)

0.03

− 1.15 (− 1.97; − 0.32)

0.01 (− 0.03; 0.05)

0.50

 FEF25–75 % (% predicted)

71.53 (65.48; 77.58)

0.43 (0.20; 0.65)

0.00

72.75 (55.33; 90.18)

− 0.24 (− 1.25; 0.76)

0.60

 FEF25–75 % (z-score)

− 1.43 (− 1.74; − 1.11)

− 0.02 (− 0.02; − 0.01)

0.00

− 2.02 (− 2.60; − 1.44)

− 0.02 (− 0.04; 0.00)

0.03

Post-bronchodilator

 FVC (% predicted)

93.96 (90.96; 96.96)

− 0.01 (− 0.16; 0.13)

0.90

89.45 (81.62; 97.28)

− 0.07 (− 0.47; 0.33)

0.70

 FVC (z-score)

− 0.42 (− 0.71; − 0.13)

− 0.01 (− 0.02; 0.00)

0.10

− 0.89 (− 1.59; − 0.19)

− 0.02 (− 0.04; 0.01)

0.30

 FEV1 (% predicted)

88.09 (84.61; 91.56)

0.06 (− 0.06; 0.18)

0.30

89.58 (80.62; 98.50)

− 0.48 (− 0.93; − 0.03)

0.04

 FEV1 (z-score)

− 0.79 (− 1.11; − 0.46)

0.00 (− 0.01; 0.01)

0.10

− 1.38 (− 2.20; − 0.55)

− 0.01 (− 0.05; 0.03)

0.70

 FEV1/FVC ratio

93.31 (90.75; 95.87)

0.09 (− 0.04; 0.23)

0.20

92.02 (85.11; 98.94)

0.04 (− 0.21; 0.30)

0.70

 FEV1/FVC ratio (z-score)

− 0.44 (− 0.71; − 0.15)

0.02 (0.00; 0.03)

0.02

− 0.45 (− 1.43; 0.52)

0.01 (− 0.05; 0.07)

0.70

 FEF25–75 % (% predicted)

90.60 (83.46; 97.75)

0.11 (− 0.24; 0.46)

0.50

87.98 (69.48; 106.47)

− 0.17 (− 1.12; 0.78)

0.70

 FEF25–75 % (z-score)

− 0.51 (− 0.87; − 0.16)

0.01 (− 0.01; 0.02)

0.30

− 0.72 (− 1.64; 0.20)

− 0.01 (− 0.05; 0.04)

0.80

 Increase in FEV1 (%)

9.48 (7.12; 11.84)

− 0.18 (− 0.32; − 0.03)

0.02

12.07 (6.18; 17.97)

− 0.28 (− 0.67; 0.11)

0.20

  1. aMonthly variation in response