Table 3 DBPCFC results of the eight patients
Results challenge | |||
|---|---|---|---|
Patient no. | Dose | Signs and symptomsa | Test outcome |
1 | Verum 3–9 | Very mild tingling on the lips | +/−; Only mild OAS symptoms; open provocation test needed |
Placebo 1–9 | – | − | |
Open provocation: ½ hazelnut | Mild tingling on tongue and lips | +/− | |
2 | Verum 4–5 | Tingling of the lips, Pruritus Mild urticaria/angioedema of the lips (11 min after verum 4) | +; Test is stopped after dose 5 because of inconvenient allergic complaints |
Placebo 1–9 | – | − | |
3 | Verum 9 | Very mild tingling on the lips | +/−; Only mild OAS symptoms; Open provocation test needed |
Placebo 1–9 | – | − | |
Open provocation: 5 hazelnuts | Raw feeling in the throat | + | |
4 | Verum 2–7 Verum 8–9 | Pruritus, urticaria lesion in the neck Sneezing, itchy nose | + |
Placebo 1–9 | – | − | |
5 | Verum 9 | Very mild tingling of the lips | +/−; Only mild OAS symptoms; Open provocation test needed |
Placebo 1–9 | – | − | |
Open provocation: 5 hazelnuts | Raw feeling in the throat | + | |
6 | Verum 1–9 | Very mild tingling of the lips | Verum and placebo challenges gave both mild OAS symptoms. This could be due to the anxiety of the patient during the challenges. Open provocation test is needed |
Verum 9 | Gastrointestinal: Nausea | ||
Placebo 1–9 | Very mild tingling of the lips | ||
Placebo 9 | Gastrointestinal: Nausea | ||
Open provocation: ½ hazelnut | Mild tingling of throat and tongue | +/− | |
7 | Verum 1–9 | – | – |
Placebo 1–9 | – | – | |
Open provocation: ½ hazelnut | Mild tingling of throat and tongue | +/− | |
8 | Verum 1–9 | ||
Placebo 1–9 | |||
Open provocation: ½ hazelnut | Urticaria: discrete blister lower lip | +/− | |