Is a positive intracutaneous test induced by penicillin mediated by histamine? A cutaneous microdialysis study in penicillin-allergic patients

Tannert, Line K.; Falkencrone, Sidsel; Mortz, Charlotte G.; Bindslev-Jensen, Carsten; Skov, Per Stahl

doi:10.1186/s13601-017-0179-2

Table 1 Demographic data and result of skin test, s-IgE, microdialysis and challenge in patients with a previous positive ICT to penicillin

From: Is a positive intracutaneous test induced by penicillin mediated by histamine? A cutaneous microdialysis study in penicillin-allergic patients

Patient	Sex	Age	Initial reaction		S-IgE				ICT previously positive	ICT positive	Histamine in eluate	Challenge		Time interval (months)
Patient	Sex	Age	Symptoms	Culprit drug	Pen V	Pen G	AMP	AX	ICT previously positive	ICT positive	Histamine in eluate	Symptoms	Drug	Initial reaction → microdialysis	First ICT → microdialysis
1	M	64	Ana	MC	< 0.35	< 0.35	< 0.35	< 0.35	MC	MC	+	ND (Ana)	−	2	0.25
2	F	46	Ana	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP	BP	+	ND (Ana)	−	6	4
3	F	46	Urt	Pen V	1.61	1.65	1.25	< 0.35	AMP, BP	AMP	−	ND (SRI)	−	91	84
4	M	58	Ana	DX	< 0.35	< 0.35	< 0.35	< 0.35	BP, DX, AMP, MC*	−	−	Positive (Urt)	DX	27	26
5	F	60	Urt + Ang	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP, AMP*	−	−	Positive (Urt)	Pen V	90	84
6	F	23	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	AX	−	−	Positive (Urt + Ang)	Pen V	5	0.5
7	F	58	Ana	Pen V	2.85	< 0.35	< 0.35	< 0.35	BP*	−	−	Positive (Urt)	Pen V	101	95
8	F	51	Urt	Pen V	2.43	< 0.35	< 0.35	< 0.35	BP, AMP, AX	BP, AMP, AX	−	Positive (Urt)	Pen V	3	0.5
9	F	50	Urt	AX + Cla	< 0.35	< 0.35	< 0.35	< 0.35	AX	AX	+	Positive (Urt)	AX + Cla	11	1
10	F	50	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP	BP	+	Positive (Urt)	Pen V	1	0.25
11	F	63	Erythema	MC	< 0.35	< 0.35	< 0.35	< 0.35	MC	MC	−	ND (DPI)	−	4	3
12	F	39	Uns. rash	DX	< 0.35	< 0.35	< 0.35	< 0.35	DX	−	−	ND (DPI)	−	17	4
13	F	70	Uns. rash	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP, MC	BP, AMP	−	ND (DPI)	−	240	0.5
14	F	46	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP	−	−	Negative	Pen V	29	24
15	M	54	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP	BP	−	Negative	Pen V	18	6
16	F	58	Urt	MC	< 0.35	< 0.35	1.64	1.19	BP, AMP, MC	−	−	Negative	MC + AMP	7	5
17	M	42	Uns. rash	AX	< 0.35	< 0.35	< 0.35	< 0.35	AX	−	−	Negative	AX	12	0.25
18	F	46	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	AX	BP	−	Negative	Pen V	9	1
19	M	48	Ana	Pen V	2.50	< 0.35	< 0.35	< 0.35	BP, AMP	−	−	ND (refused)	−	40	39
20	M	55	Ana	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP*	−	−	ND (refused)	−	82	79
21	F	45	Urt	Pen V	< 0.35	< 0.35	< 0.35	< 0.35	BP, AMP	−	−	ND (refused)	−	33	32

Age refers to patients’ age at the day of microdialysis. Challenge refers to challenge with penicillin performed after microdialysis. * Not skin tested with amoxicillin because it was not available at the time of testing. Patient 16 was challenged at two separate occasions
Pen V penicillin V, Pen G penicillin G, AMP ampicillin, AX amoxicillin, MC mecillinam, Ana recent anaphylaxis, DPI delayed positive ICT, SRI systemic reaction during ICT, Urt urticaria, Ang angioedema, ND not done

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ISSN: 2045-7022

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