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Table 3 Summary of evidence to support the effectiveness of AIT

From: Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic overview of systematic reviews

Study ID SLIT SCIT
Calderon et al. [25] NA +++
Di Bona et al. [27] +/− NA
Di Bona et al. [26] +/− NA
Dranitsaris et al. [37] ++ (indirect analysis) NA
Dretzke et al. [36] +++ +++
Erekosima et al. [22] NA ++/+++
Feng et al. [23] NA
Kim et al. [35] ++ ++
Lin et al. [28] ++ NA
Meadows et al. [34] ++ (only in adults) ++ (only in adults)
Purkey et al. [24] NA +++
Radulovic et al. [29] ++/+++ NA
Röder et al. [38] a
Sopo et al. [32] +/++ NA
Wilson et al. [31] ++ (only in adults) NA
Zhang (2014) ++ (MS)/− (SS) NA
  1. Effectiveness is overall referred to symptom and medication scores unless otherwise stated
  2. +++, Strong evidence; ++, Moderate evidence; +, Some/limited evidence; +/−, Unclear evidence; –, No evidence; SS, symptom scores; MS, medication scores
  3. aSame results were referred also to oral immunotherapy and intranasal immunotherapy