Allergen immunotherapy for allergic rhinoconjunctivitis: a systematic overview of systematic reviews

Table 2 Critical appraisal of included systematic reviews (N = 17)

References	Focused question	Inclusion of appropriate studies	Inclusion of eligible studies	Quality assessment of studies	Appropriateness of synthesis	Overall results of review	Applicability to local populations	Considering all relevant outcomes	Benefits versus harms/costs	Overall quality assessment
Calderon et al. [25]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Di Bona et al. [27]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Di Bona et al. [26]	✓	✓	X	✓	✓	✓	n/a	✓	n/a	Moderate
Dranitsaris et al. [37]	✓	✓	Unclear	Unclear	✓	✓	n/a	✓	✓	Low
Dretzke et al. [36]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Erekosima et al. [22]	✓	✓	✗	✓	n/a	✓	n/a	✓	✓	Moderate
Feng et al. [23]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Hoeks et al. [30]
Kim et al. [35]	✓	✓	✗	✓	✓	✓	n/a	✓	✓	Moderate
Lin et al. [28]	✓	✓	✗	✓	✓	✓	n/a	✓	✓	Moderate
Meadows et al. [34]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Purkey et al. [24]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Radulovic et al. [29]	✓	✓	✓	✓	✓	✓	n/a	✓	✓	High
Roder et al. [38]	✓	✓	Unclear	Unclear	✓	✓	n/a	✓	n/a	Low
Sopo et al. [32]	✓	✓	✓	✓	✓	✓	n/a	✓	n/a	High
Wilson et al. [31]	✓	✓	Unclear	Unclear	Unclear	✓	n/a	✓	✓	Low
Zhang et al.[33]	✓	✓	✓	Unclear	✓	✓	n/a	✓	n/a	Moderate

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