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Table 2 Total number of antibiotic prescriptions and GP contacts in primary care per patient year (absolute effect)

From: The impact of penicillin allergy labels on antibiotic and health care use in primary care: a retrospective cohort study

Outcomes Total n = 5010 Pen-A patients n = 1254 Non-Pen-A patients n = 3756 Unadjusted B 95% CI Adjusted Ba 95% CI
No. of AB per PY (%)d 2110 (100.0%) 1051 (100.0%) 1059 (100.0%) 0.556 0.377 to 0.736 0.392 0.183 to 0.600
No. of 2nd choice AB per PYb (%)d 269.4 (5.4%) 93.7 (7.5%) 175.7 (4.7%) 0.039 −0.005 to 0.084 0.024 0.008 to 0.111
Various types of antibiotics: No. of AB per PY(%)d
 Tetracyclins 332 (15.7%) 136 (12.9%) 195 (18.4%) 0.057 0.036 to 0.078 0.029 0.005 to 0.053
 BL, penicillins 501 (23.7%) 142 (13.5%) 372 (35.1%) 0.014 −0.008 to 0.037 −0.023 −0.049 to 0.002
 BL, others 21 (1.0%) 7 (0.7%) 14 (1.3%) 0.002 −0.010 to 0.013 0.004 −0.010 to 0.018
 Sulfonamides/trimethoprim 140 (6.6%) 70 (6.7%) 71 (6.7%) 0.037 0.022 to 0.051 0.027 0.010 to 0.043
 Macrolidesc 537 (25.4%) 458 (43.6%) 78 (7.4%) 0.345 0.176 to 0.514 0.263 0.066 to 0.60
 Quinolones 195 (9.2%) 78 (7.4%) 116 (11.0%) 0.032 0.000 to 0.063 0.034 −0.002 to 0.007
 Other antibacterials 373 (17.7%) 159 (15.1%) 214 (20.2%) 0.070 0.045 to 0.096 0.058 0.029 to 0.087
 No. of GP contacts per PY 6.3 16.0 3.0 3.732 3.089 to 4.375 3.052 2.316 to 3.788
  1. Pen-A penicillin allergy label, B regression coefficient per patient year, No. number, AB antibiotic prescriptions, PY patient year, BL beta-lactam, GP general practitioner, OR odds ratio, CI confidence interval
  2. Italic values represent significant differences between Pen-A and non-Pen-A
  3. aAdjusted for gender, age >12 years, comorbidities (R96, R97, S87, F71, A12), GP practice, ≥4 GP contacts/year
  4. b2nd choice AB based on Dutch guidelines for primary care. Data obtained by matching AB prescriptions with corresponding ICPC-codes
  5. cLincosamides and streptogramins included
  6. dPercentage of total number of AB prescriptions per year