|
Outcomes
|
Total n = 5010
|
Pen-A patients n = 1254
|
Non-Pen-A patients n = 3756
|
Unadjusted B
|
95% CI
|
Adjusted Ba
|
95% CI
|
|---|
|
No. of AB per PY (%)d
|
2110 (100.0%)
|
1051 (100.0%)
|
1059 (100.0%)
|
0.556
|
0.377 to 0.736
|
0.392
|
0.183 to 0.600
|
|
No. of 2nd choice AB per PYb (%)d
|
269.4 (5.4%)
|
93.7 (7.5%)
|
175.7 (4.7%)
|
0.039
|
−0.005 to 0.084
|
0.024
|
0.008 to 0.111
|
|
Various types of antibiotics: No. of AB per PY(%)d
|
|
Tetracyclins
|
332 (15.7%)
|
136 (12.9%)
|
195 (18.4%)
|
0.057
|
0.036 to 0.078
|
0.029
|
0.005 to 0.053
|
|
BL, penicillins
|
501 (23.7%)
|
142 (13.5%)
|
372 (35.1%)
|
0.014
|
−0.008 to 0.037
|
−0.023
|
−0.049 to 0.002
|
|
BL, others
|
21 (1.0%)
|
7 (0.7%)
|
14 (1.3%)
|
0.002
|
−0.010 to 0.013
|
0.004
|
−0.010 to 0.018
|
|
Sulfonamides/trimethoprim
|
140 (6.6%)
|
70 (6.7%)
|
71 (6.7%)
|
0.037
|
0.022 to 0.051
|
0.027
|
0.010 to 0.043
|
|
Macrolidesc
|
537 (25.4%)
|
458 (43.6%)
|
78 (7.4%)
|
0.345
|
0.176 to 0.514
|
0.263
|
0.066 to 0.60
|
|
Quinolones
|
195 (9.2%)
|
78 (7.4%)
|
116 (11.0%)
|
0.032
|
0.000 to 0.063
|
0.034
|
−0.002 to 0.007
|
|
Other antibacterials
|
373 (17.7%)
|
159 (15.1%)
|
214 (20.2%)
|
0.070
|
0.045 to 0.096
|
0.058
|
0.029 to 0.087
|
|
No. of GP contacts per PY
|
6.3
|
16.0
|
3.0
|
3.732
|
3.089 to 4.375
|
3.052
|
2.316 to 3.788
|
-
Pen-A penicillin allergy label, B regression coefficient per patient year, No. number, AB antibiotic prescriptions, PY patient year, BL beta-lactam, GP general practitioner, OR odds ratio, CI confidence interval
- Italic values represent significant differences between Pen-A and non-Pen-A
-
aAdjusted for gender, age >12 years, comorbidities (R96, R97, S87, F71, A12), GP practice, ≥4 GP contacts/year
-
b2nd choice AB based on Dutch guidelines for primary care. Data obtained by matching AB prescriptions with corresponding ICPC-codes
-
cLincosamides and streptogramins included
-
dPercentage of total number of AB prescriptions per year
