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Fig. 2 | Clinical and Translational Allergy

Fig. 2

From: Application of the adverse outcome pathway (AOP) concept to structure the available in vivo and in vitro mechanistic data for allergic sensitization to food proteins

Fig. 2

Molecular initiating events (MIE) that initiate food sensitization. a Food allergen interaction with mucosal surfaces of the gut intestine may result in disruption of tight junctions, receptor mediated or unspecific transcellular transport of food allergens across the gut epithelium. These events can be the initiating events that results in the activation of epithelial and innate cells such as dendritic cells. b Mechanisms and cells involved in intestinal protein transport in non-sensitized individuals. Solid boxes represent events with substantial evidence of being involved in food protein transport. Dashed boxes represent events that are possibly involved in food protein transport. Crosses indicate events and cell types of which there is no indication that they play a role in the transport of food proteins across the gut barrier in non-sensitized individuals

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