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Table 3 Frequency of side effects per antihistamine

From: Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria

Antihistamine Frequency n (%) Somnolence n (%) Other n (%) Other side effects
Levocetirizine 5 mg 28 (22) 22 (17) 6 (5) Weight gain (n = 2), palpitations, increase of symptoms, unclear (n = 2)
Desloratadine 5 mg 14 (14) 9 (9) 5 (5) Palpitations, headache, increase of symptoms (n = 2), unclear (n = 2)
Fexofenadine 180 mg 2 (5) 1 (2) 1 (2) Increase of symptoms
Clemastine 1 mg 3 (9) 2 (6) 1 (3) Increased intra-ocular pressure
Hydroxyzine 25 mg 3 (12) 3 (12) 0 (0) n.a.
Cetirizine 10 mg 0 (0) 0 (0) 0 (0) n.a.
Loratadine 10 mg 1 (11) 1 (11) 0 (0) n.a.
Acrivastine 3 × 8 mg 0 (0) n.a n.a n.a.
  1. Data are presented as numbers and percentages of patients treated with this antihistamine. Patients may have reported side effects upon treatment with more than one antihistamine, therefore the numbers do not match the total number of patients reporting at least one side effect. “Other” side effects occurred in one patient each, unless otherwise specified. Percentages are rounded and may therefore not match within one row. Please note that a low frequency of side effects may be due to a low frequency of use for the specific antihistamine, and to a lack of updating in the study population since only patient-reported side effects were shown