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Table 2 Frequency of use and frequency of satisfying result per antihistamine

From: Effectiveness and safety of antihistamines up to fourfold or higher in treatment of chronic spontaneous urticaria

Antihistamine Frequency n (%) Sufficient effect of licensed dose n (%) Sufficient effect after up-dosing n (%) Dose with sufficient effect median (range)
Levocetirizine 5 mg 126 (71) 15 (12) 26 (21) 2 (0–6)
Desloratadine 5 mg* 99 (56) 1 (1) 15 (15) 4 (1–6)
Fexofenadine 180 mg 41 (23) 5 (12) 2 (5) 1 (0–2)
Clemastine 1 mg 35 (20) 1 (3) 2 (6) 2 (1–2)
Hydroxyzine 25 mg 26 (15) 0 (0) 1 (4) 3 (n.a.)
Cetirizine 10 mg* 16 (9) 2 (13) 2 (13) 1.5 (1–4)
Loratadine 10 mg 9 (5) 0 (0) 1 (11) 2 (n.a.)
Acrivastine 3 × 8 mg 2 (1) 0 (0) 0 (0) n.a.
  1. Frequency data are presented as numbers and percentages of the total population (n = 178), and frequencies of sufficient response are presented as percentages of those treated with the specific antihistamine
  2. * In 1 patient it was unknown which dose caused sufficient effect. n.a. not applicable. Please note that in most patients where up-dosing higher than fourfold occurred, this was done by combining more than one type of antihistamine. In these cases the effect of one specific antihistamine was unclear and was not included in this analysis