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Fig. 2 | Clinical and Translational Allergy

Fig. 2

From: Exploratory analysis of CD63 and CD203c expression in basophils from hazelnut sensitized and allergic individuals

Fig. 2

Expression of CD63 and CD203c normalized for basophil activation induced by the positive control (anti-IgE). a, b The dose–response curves for CD63 (a) and CD203c (b). The values are shown as medians. For a clear picture, the ranges are not shown in a and b. The net values are depicted in Additional file 1: Figure S1 as medians with interquartile ranges for the four groups. The vertical dotted line indicates the maximum CD63 expression (CD-max) at the hazelnut (HN) concentration of 0.1 µg/ml (a), and the horizontal dotted line gives the concentration required to activate 30% of CD203c+ basophils [effective concentration (EC)30] (b). c, d The comparison between the sensitized (n = 20) and symptomatic (OAS and systemic, n = 32) groups by c Maximum CD63 expression (CD-max) at 0.1 μg/ml of hazelnut (HN) extract and d HN extract concentrations that activated 30% of basophils (EC30). Statistical significances were analyzed with Mann–Whitney U test

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