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Fig. 1 | Clinical and Translational Allergy

Fig. 1

From: Immunoglobulin free light chains in adult atopic dermatitis patients do not correlate with disease severity

Fig. 1

Serum kappa Ig-FLC and total IgE levels in AD patients and non-atopic controls. a A Students’ t test showed no significant differences between the levels of kappa Ig-FLCs in AD patients (n = 82; median 23.63 µg/ml, IQR: 16.45–30.43) compared to non-atopic controls (n = 49; 15.66 µg/ml, IQR: 10.95–21.38). Total IgE levels in AD patients (median 2702.00 kU/l, IQR: 921.3–8579) were significantly higher compared to non-atopic controls (median 34.05 kU/l, IQR: 12.90–75.05), according to a students’ t test (p = 0.0001). b, c Kappa Ig-FLC concentrations showed a small non-significant decrease from 23.63 to 16.20 µg/ml (median) after treatment (p = 0.17). No significant changes were observed between total IgE levels before and after treatment (p = 0.22) (b). Disease severity measured by SASSAD and BSA, significantly decreased during a clinical admission and treatment with topical steroids (n = 32). Levels of serum biomarkers TARC, PARC, sIL-2R, and IL-22 also significantly decreased. c Data were analyzed using a Wilcoxon matched-pairs signed rank test

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