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Table 11 Clinical information and functional assays results from three hypersensivity patients to antibiotics

From: 7th Drug hypersensitivity meeting: part two

Patient information Lymphocyte transformation test Change in the pattern of expresion of miRNAs with drugs
Code Sex Age Skin reaction SI/Drug (μg/ml) miRNA Drug (μg/ml) Relative expression Time (h)
SMX1 F 60 MPE 5.0/SMX (200)
5.2/SMX-NO (20)
142 SMX (400) 153 ± 28 12
      18a SMX-NO (12) 71.6 ± 1.21 24
      155 SMX-NO (12) 5.6 ± 1.1 24
SMX2 M 35 MPE 2.0/SMX (400)
3.0/SMX-NO (20)
18a SMX (400) 2.5 ± 0.6 24
      21 SMX-NO (12) 6.3 ± 3.2 24
      142 SMX (400) 3.9 ± 0.7 24
LVF1 M 47 MPE 2.0/LVF (10) 142 LVF (10) 12.2 ± 0.9 24
      18a LVF (10) 4.0 ± 0.4 48
      155 LVF (10) 5.1 ± 1.1 48
  1. Relative expression results are presented as the Mean ± SD obtained by the delta Cq method
  2. SMX sulfamethoxazole, SMX-NO sulfamethoxazole nitroso, LVF levofloxacin, MPE maculopapular exanthema