Fig. 1

Change in UPDD Weekly Sleep Interference Score. a ASTERIA I, b ASTERIA II, and c GLACIAL. Arrows represent omalizumab dosing. Low numbers represent good quality sleep. Least-squares means were derived from a repeated-measures model adjusted for baseline value (less than median, greater than or equal to median) and baseline weight (<80, ≥80 kg). Statistical significance is marked every 4 weeks to minimize the visual burden of the graph. However, the following endpoints demonstrated statistical significance, in addition to the ones marked on the graph: ASTERIA I: all time points for omalizumab 300 mg during treatment and follow-up weeks 25, 34, 37 and 38; weeks 9, 10, 11, and 13 for omalizumab 150 mg; and weeks 26, 27, 29, 30, 31, 33, 34, 37 for omalizumab 75 mg; ASTERIA II: all time points for omalizumab 300 mg during treatment and follow-up weeks 13–15; weeks 1, 2, 3, 5, 6, 7, 9, 10, 11, 13, and 21 for omalizumab 150 mg; and weeks 1, 2, 10, 13, and 21 for omalizumab 75 mg; GLACIAL: all time points during treatment and follow-up weeks 25, 26, 27, 29, 30, and 31 for omalizumab 300 mg. *p < 0.05; **p < 0.001; ***p < 0.01, versus placebo. UPDD Urticaria Patient Daily Diary