Optimizing diagnostic tests for persulphate-induced respiratory diseases

Table 3 Characteristics of hairdressers with a negative specific inhalation challenge

ID	Age (y)	WRAS	WRRS	Stop/resume test	Duration of exposure before symptoms (y)	Time from exposure to symptoms	Time since last exposure to persulphates (y)	Baseline FEV1/FVC (% of pred.)
1	52	+	+	N	3	Within hours	5	86 (109 %)
3	45	+	+	P	20	Within hours	CE	83 (104 %)
4	49	+	+	P	28	Within minutes	CE	65 (81 %) Rever: 2.9 %
6	30	–	+	P	10	Within minutes	3	81 (97 %)
7	27	+	+	P	1	Not definable	1	84.9 (103.3 %)
9	20	+	+	P	1	Within minutes	CE	98 (116 %)
11	43	+	+	P	20	Within hours	CE	83 (103 %)
12	23	+	+	N	3	Within hours	CE	74 (88 %) Rever: 12 %
13	46	+	–	N	2	Not definable	3	83 (103 %)
14	27	+	+	P	7	Within minutes	CE	83 (99 %)
15	31	+	+	P	4	Within minutes	1/2	75 (90 %) Rever: 7.8 %
17	20	+	+	P	4	Not definable	1/6	91 (108 %)
18	29	+	+	P	8	Within hours	CE	91 (109 %)

ID	Age (y)	MCh PD20 (µg)	FeNO (ppb)	T-IgE (kU/L)	Atopy^a	HRT PP (mg/mL)	HRT SP (mg/mL)	HRT AP (mg/mL)
1	52	N	25	3.6	No	1.25	0.63	1.25
3	45	N	9.9	6.7	No	N	5.0	2.5
4	49	N	16.0	2.2	No	10.0	10.0	5.0
6	30	400	64.1	155	No	N	10.0	5.0
7	27	N	19.3	127	D	N	5.0	2.5
9	20	N	6.6	<2	No	N	10.0	5.0
11	43	N	7.1	22.5	No	N	10.0	5.0
12	23	N	21.8	122	No	10.0	5.0	2.5
13	46	626	12.1	35.4	No	N	5.0	1.25
14	27	N	11.8	3.7	No	N	10.0	5.0
15	31	720	9.0	308	D	5.0	2.5	1.25
17	20	N	9.0	4.3	No	10.0	2.5	2.5
18	29	N	19.7	58.3	No	N	N	N

y years, WRAS work-related asthma symptoms, WRRS work-related rhinitis symptoms, MCh methacholine challenge, FeNO fractional exhaled nitrogen oxide (increased values in italics), T-IgE total immunoglobulin E, HRT histamine release test, PP potassium persulphate, AP ammonium persulphate, SP sodium persulphate, SIC specific inhalation challenge, N negative, P positive, CE currently exposed, D dermographism, R rhinitis, A asthma
^aDefined as ≥1 positive SPT to common inhalant allergens

ISSN: 2045-7022