Optimizing diagnostic tests for persulphate-induced respiratory diseases

Table 2 Characteristics of hairdressers with a positive specific inhalation challenge

ID	Age (y)	WRAS	WRRS	Stop/resume test	Duration of exposure before symptoms (y)	Time from exposure to symptom	Time since last exposure to persulphates (y)	Baseline FEV1/FVC (% of pred.)	MCh PD20 (µg)
2	21	+	+	P	5	Within hours	CE	87 (103 %)	330
5	29	+	+	P	11	Not definable	CE	86.7 (104 %)	N
8	32	+	+	P	1.5	Within minutes	8	85.5 (103 %)	346
10	22	+	+	P	4–5	Within hours	CE	80.6 (96 %)	N
16	23	+	+	P	0.5–1	Within minutes	2	85.4 (101 %) Rever: 12 %	N
19	23	+	+	P	0.5–1	Within minutes	1/3	94.9 (113 %)	N

ID	Age (y)	FeNO (ppb)	T-IgE (kU/L)	Atopy^a	HRT PP (mg/mL)	HRT SP (mg/mL)	HRT AP (mg/mL)	SIC response	Classification of SIC response
2	21	6.3	73.2	No	N	N	2.5	R A	4 and 8 after 3rd exposure (late reaction)
5	29	6.2	8.7	Yes	N	10.0	10.0	R	1 h after 3rd exposure (immediate reaction)
8	32	31.2	46.4	Yes	N	N	5.0	R	1 h after 3rd exposure (immediate reaction)
10	22	7.4	26.6	No	N	N	10.0	R A	1 and 3 h after 3rd exposure (immediate reaction/late reaction)
16	23	13.0	39.8	Yes	10.0	2.5	1.25	R	After 2nd exposure (immediate reaction)
19	23	16.9	63.6	Yes	0.63	–	0.63	R	After 3rd exposure (immediate reaction)

y years, WRAS work-related asthma symptoms, WRRS work-related rhinitis symptoms, MCh methacholine challenge, FeNO fractional exhaled nitrogen oxide (increased values in italics), T-IgE total immunoglobulin E, HRT histamine release test, PP potassium persulphate, AP ammonium persulphate, SP sodium persulphate, SIC specific inhalation challenge, N negative, P positive, CE currently exposed, R rhinitis, A asthma
^aDefined as ≥1 positive SPT to common inhalant allergens

ISSN: 2045-7022