|
Gastrointestinal [54]
|
Non-invasive, does not harm animals, qualitative and quantitative allergy scoring, blinded scoring possible
|
No standardized scoring system, lab to lab variations, subjective, diarrhea as only GI specific sign
|
|
Systemic
|
|
Anaphylaxis score [76]
|
Non-invasive, qualitative and quantitative allergy scoring, blinded scoring possible
|
Subjective, ethical consideration
|
|
Hypothermia [109, 110]
|
Rectal temperature (semi-invasive), quantitative readout, blinded scoring possible
|
Accuracy of rectal measurements, transplanted responders (invasive), ethical consideration
|
|
Vascular leakage [24, 110]
|
Qualitative readout, blinded scoring possible
|
Invasive
|
|
Airways
|
|
AHR [105]
|
Qualitative and quantitative, objective readout, blinded measurements are possible, anesthesia not required for non-invasive AHR
|
Invasive and anesthesia required (only for invasive AHR), usually endpoint measurement, expensive equipment required
|
|
Skin [111]
|
|
PCA
|
Quantitative measurement of skin thickness, qualitative assessement of vascular leakage
|
Invasive, blinded scoring not possible
|
|
ITH
|
Quantitative measurement of skin swelling
|
Invasive, blinded scoring not possible
|
|
DTH
|
Quantitative measurement of skin/tissue swelling
|
Invasive, blinded scoring not possible
|
