Table 3 Selection of most significant differential methylated regions found in >1 group with delta >0.01
From: Cow’s milk allergy in Dutch children: an epigenetic pilot survey
Genea | Chromosome | Delta | p | Overlap | Function obtained from genecards | Valb |
|---|---|---|---|---|---|---|
OR5M8 | 11 | 0.010 0.012 | 7.7E−06 1.6E−04 | Exon1 (combined) Exon1 (girl) | Codes for olfactory receptor located in the nose. Is involved in many neurotransmitter and hormone receptors and are responsible for the recognition and transduction of odorant signals | No |
ZNF281 | 1 | 0.024 0.034 | 1.2E−04 1.3E−06 | Exon1 (combined) Exon1 (boy) | Transcription repressor. Represses the transcription of a number of genes including GAST, ODC1 and VIM | Yes |
KIAA1324L | 7 | 0.012 0.016 | 4.8E−04 3.2E−04 | Exon1 (combined) Exon1 (boy) | Estrogen-Induced protein-coding gene | No |
EIF4E2 | 2 | 0.027 0.036 | 2.6E−05 1.0E−04 | Gene body (combined) Gene body (girl) | Diseases associated with EIF4E2 include lung cancer, and among its related super-pathways are Interferon Signaling and Transcription Receptor-mediated HIF regulation | Yes |
HTR2A | 13 | 0.051 0.069 | 6.4E−05 8.1E−05 | Gene body (combined) Gene body (girl) | Receptors for serotonin, a hormone that functions as a neurotransmitter and a mitogen. This receptor is involved in tracheal smooth muscle contraction, bronchoconstriction, and control of aldosterone production | Yes |
ZNF366 | 5 | 0.022 0.033 | 2.2E−05 1.6E−04 | TSS1500 (combined) TSS1500 (girl) | Transcription repressor. Associated diseases include breast cancer, and prostatitis | No |
DHX58 | 17 | −0.061 −0.061 −0.085 −0.085 | 3.1E−04 3.1E−04 3.3E−04 3.4E−04 | 3′-UTR (combined) SSHELF (combined) 3′-UTR (boy) SSHELF (boy) | Involved in the innate immune response to various RNA viruses and some DNA viruses | Yes |
PRB4 | 12 | −0.012 −0.015 | 6.3E−04 5.2E−04 | 3′-UTR (combined) 3′-UTR (boy) | The protein encoded by this gene is a proline-rich salivary protein | No |
DNM1 | 9 130996210–130996443 | −0.022 −0.028 | 7.2E−05 2.4E−04 | ISLAND (combined) ISLAND (boy) | The encoded protein possesses unique mechanochemical properties used to tubulate and sever membranes, and is involved in clathrin-mediated endocytosis and other vesicular trafficking processes | No |
WNT10A | 2 219762987–219763537 | 0.038 0.039 | 9.0E−05 4.1E−04 | SSHELF (combined) SSHELF (boy) | These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis | No |