Cow’s milk allergy in Dutch children: an epigenetic pilot survey

Table 1 Characteristics of Dutch allergy study population; cow’s milk allergy versus controls

	CMA	Controls	p	Tolerant	Tolerant control boys	p
N (♀)^a	20 (8)	20 (10)	0.342	10 (0)	13 (0)	NA
Age diagnosis CMA ± SD^b	6.5 ± 2.5	NA	NA	5.8 ± 2.2	NA	NA
Age at sampling ± SD^b	11.8 ± 4.8	17.2 ± 7.1	0.008	18.0 ± 5.5	17.2 ± 4.3	0.714
N of children with CMP sIgE > 0.35 kU/L^c	7	1	0.044	2	1	0.560
Mean CMP sIgE value ± SD (kU/L)	1.15 ± 3.6	0.16 ± 0.64	0.260	0.19 ± 0.39	0.23 ± 0.79	0.693
Range CMP sIgE value (kU/L)	16.4	2.9	NA	1.0	2.9	NA
Maternal smoking^d			0.659			0.483
Pregnancy	2	3		1	2
Before pregnancy	5	5		2	4
Never	13	12		7	7
Maternal vitamin D^d			0.317			NA
Regular	0	0		0	0
Period only	0	0		0	0
Irregular	1	0		0	0
None	19	20		10	13
Maternal multivitamin^d			0.836			0.883
Regular	12	11		1	5
Period only	2	2		4	3
Irregular	1	1		0	0
None	5	6		5	5
Maternal folic acid^d			0.656			0.012
Regular	8	9		0	5
Period only	9	9		10	6
Irregular	1	0		0	0
None	2	2		0	2

Significant p-values <0.05 are in italic
NA not applicable, CMA cow’s milk allergy, p p value, SD standard deviation, N number, CMP cow’s milk protein
^aPearson Chi square test
^bAge in months ANOVA
^cFisher’s exact test, 2-sided
^dPearson Chi square test for trend

ISSN: 2045-7022