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Table 1 Number of basophils (gated as SSClow/CD123+/HLA-DR− cells) and expression of CD123 on the surface of basophils (gated as SSClow/CD203c+ cells) as measured by MFI of CD123-FITC in different stimulation conditions

From: The expression of CD123 can decrease with basophil activation: implications for the gating strategy of the basophil activation test

Stimulant n Pre-stimulation Post-stimulation p value
Number of basophils
 fMLP 116 1722 (1226, 2184) 1572 (1037, 2100) 0.012
 Anti-IgE 104 1722 (1221, 2191) 1414 (972, 1995) 0.005
 Peanut extract 42 1732 (1212, 2174) 1514 (914, 2041) 0.134
MFI of CD123-FITC
 fMLP 116 1082 (98, 1549) 514 (75, 1020) <0.001
 Anti-IgE 104 1081 (95, 1549) 495 (60, 1111) <0.001
 Peanut extract 42 1172 (80–2058) 293 (40, 1244) <0.001
  1. Median (inter-quartile range) is represented. p value refers to the comparison of post-stimulation conditions with the negative control
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Clinical and Translational Allergy

ISSN: 2045-7022

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