Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

Table 2 Selected filaggrin mutations according Sandilands et al.

FLG mutation	Amplicon	Repeat	g. (H19)	c.	ATG	bp	p.	Ethnicity^b
R501X	FLG-1	1	152285861	1501	2072	C>T	501	EUR/AM
2282del4	FLG-2	1	152285080	2282	2853	del4 (CAGT-2286)	761/762	EUR/AM
3702delG	FLG-3	3	152283660	3702	4273	delG	1234	IR
R1474X	FLG-4	4	152282942	4420	4991	C>T	1474	IR
5360delG	FLG-5	5	152282002	5360	5931	delG	1787	NL
6867delAG	FLG-6	6	152280495	6867	7438	delAG (AG-2268)	2289/2290	AUS
E2422X	FLG-7	7	152280098	7264	7835	G>T	2422	NL
7267delCA	FLG-7	7	152280095	7267	7838	delCA (CA-7268)	2423	NL
R2447X	FLG-7	7	152280023	7339	7910	C>G	2447	IR
S3247X	FLG-8	9	152277622	9740	10311	C>A	3247	IR
11029delCA	FLG-9	10	152276333	11029	11600	delCA (CA-11030)	3677	IR
11033del4	FLG-9	10	152276329	11033	11604	Del4(CAGT-11036)	3678/3679	NL
Q3683X	FLG-9	10	152276312	11050	11050	C>T	3684^a	Ir

^aSandilands reported p. 3683. FLG filaggrin, g genomic position, c coding postion, ATG distance from transcription start site, bp basepair change(s), p. affected amino acid
^bEthnic group were mutations were first reported, adapted from Sandilands et al. EUR (European), AM (American.), IR (Irish), AUS (Austrian), NL (Dutch)