Skip to main content

Table 2 Selected filaggrin mutations according Sandilands et al.

From: Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

FLG mutation Amplicon Repeat g. (H19) c. ATG bp p. Ethnicityb
R501X FLG-1 1 152285861 1501 2072 C>T 501 EUR/AM
2282del4 FLG-2 1 152285080 2282 2853 del4 (CAGT-2286) 761/762 EUR/AM
3702delG FLG-3 3 152283660 3702 4273 delG 1234 IR
R1474X FLG-4 4 152282942 4420 4991 C>T 1474 IR
5360delG FLG-5 5 152282002 5360 5931 delG 1787 NL
6867delAG FLG-6 6 152280495 6867 7438 delAG (AG-2268) 2289/2290 AUS
E2422X FLG-7 7 152280098 7264 7835 G>T 2422 NL
7267delCA FLG-7 7 152280095 7267 7838 delCA (CA-7268) 2423 NL
R2447X FLG-7 7 152280023 7339 7910 C>G 2447 IR
S3247X FLG-8 9 152277622 9740 10311 C>A 3247 IR
11029delCA FLG-9 10 152276333 11029 11600 delCA (CA-11030) 3677 IR
11033del4 FLG-9 10 152276329 11033 11604 Del4(CAGT-11036) 3678/3679 NL
Q3683X FLG-9 10 152276312 11050 11050 C>T 3684a Ir
  1. aSandilands reported p. 3683. FLG filaggrin, g genomic position, c coding postion, ATG distance from transcription start site, bp basepair change(s), p. affected amino acid
  2. bEthnic group were mutations were first reported, adapted from Sandilands et al. EUR (European), AM (American.), IR (Irish), AUS (Austrian), NL (Dutch)