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Table 1 Candidate SNPs

From: Genetic susceptibility for cow’s milk allergy in Dutch children: the start of the allergic march?

SNP Chr Genotype* HWP Nearby gene(s): function
rs2155219 a 11 G/G: 0,30
G/T: 0,43
0.15 C11orf30: Regulator, represses transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. LRRC32: Associated with allergic rhinitis and rhinitis
rs17616434 b 4 C/C: 0,06
C/T: 0,31
T/T: 0,62
0.371 TLR10: Toll Like Receptor 10. Pathogen activation, activation innate immunity. TLR1: Toll Like Receptor 1. Specifically recognizes diacylated and triacylated lipopeptide. TLR6: Toll Like Receptor 6. This receptor functionally interacts with toll-like receptor 2. associated with an increased risk of asthma in some populations. FAM114A1: May play a role in neuronal cell development
rs6586513 a 1 A/A: 0,51
A/C: 0,49
0.15 CROCC: Major structural component of the ciliary rootlet. Contributes to centrosome cohesion before mitosis. ATP13A2: ATPase Type 13A2. Transports inorganic cations and other substrates. SDHB: succinate dehydrogenase complex. Complex 2 of respiratory chain. MFAP2: Microfibrillar-associated protein. Major antigen of elastin-associated microfibrils
rs3860069 a 4 A/A: 0,50
A/C: 0,45
C/C: 0,05
0.343 TLR6: Toll Like Receptor 6. This receptor functionally interacts with toll-like receptor 2. associated with an increased risk of asthma in some populations. TLR10: Toll Like Receptor 10. Pathogen activation, activation innate immunity. TLR1: Toll Like Receptor 1. Specifically recognizes diacylated and triacylated lipopeptide. FAM114A1: May play a role in neuronal cell development
rs6898653 a 5 A/A: 0,59
A/G: 0,36
G/G: 0,05
1 SEMA6A: expression in developing neuronal tissue. Is required for proper development of the thalamocortical projection
rs2069772 a 4 A/A: 0,52
A/G: 0,38
G/G: 0,10
0.527 IL2: Interleukin 2. Secreted cytokine for proliferation of T and B lymphocytes. Produced by T cells. ADAD1: binds to RNA. Plays a role in spermatogenesis. KIAA1109: associated with celiac disease
  1. Chr chromosome
  2. * CEU genotype, NCBI database, HWP Hardy–Weinberg p value, NCBI database
  3. acandidate SNP earlier reported by Ramasamy. A. 2011
  4. bcandidate SNP earlier reported by Bønnelykke K. 2013