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Table 1 Primary nasal epithelial cells of 5 non-allergic individuals were stimulated for 24 h with different TLR ligands: TLR2 (PGN: 10 μg/ml), TLR3 (Poly(I:C): 20 μg/ml), TLR4 (LPS 1 μg/ml)

From: Expression profiling and functional analysis of Toll-like receptors in primary healthy human nasal epithelial cells shows no correlation and a refractory LPS response

  Cut off value IMDM Poly(I:C) LPS PGN
Mean SD Mean SD Mean SD Mean SD
IL-1β 20 BD   26 28 BD   BD  
IL1RA 15 198 151 713** 487 219 111 337** 179
IL-2 3 BD   13 15 BD   BD  
IL-4 3 BD   13** 12 BD   BD  
IL-5 2 BD   BD   BD   BD  
IL-6 3 351 331 1793** 1491 264 256 548** 521
IL-7 3 24 36 132 122 34 35 45 44
IL-10 16 BD   BD   BD   BD  
IL-12 8 BD   46 27 BD   BD  
IL-13 4 BD   BD   BD   BD  
IL-15 6 BD   28 27 BD   BD  
IL-17 7 17 19 26 32 11 17 10 20
Eotaxin 6 BD   BD   BD   BD  
FGF basic 15 BD   40** 40 BD   BD  
G-CSF 2 72 95 655** 700 BD   132 179
GMCSF 4 36 74 58 148 18 47 20 48
INF γ 80 BD   BD 16 BD   BD  
IP-10 24 BD   1982** 1666 BD   29 27
MCP 1 6 219 111 414 456 204 107 278 216
MIP1α 2 8 16 1122 2376 4 10 4 11
MIP1β 38 BD   930** 1321 BD   BD  
MIG 4 5 11 23 22 BD   BD  
RANTES 5 19 23 2120** 1516 18 21 25 25
TNFα 10 BD   43 68 BD   BD  
VEGF 9 191 163 482** 508 161 142 262** 189
EGF 1 BD   5 10 BD   1 4
HGF 66 BD   31 28 BD   BD  
IL-2R 7 70 52 632** 491 65 36 99 63
IFNα 2 14 21 39 39 10 18 22 20
  1. Cell free supernatants were analysed using a Luminex array. Concentrations are presented as average of triplicates of 5 different patients in pg/ml. The detection limits are shown as cut off value
  2. SD Standard deviation, BD below detection level
  3. ** P < 0.05