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Table 3 Summary of calculated PK parameters

From: Interchangeability and comparative effectiveness between generic and brand montelukast immediate release tablets after a single oral administration in healthy volunteers

Parameters (unit) Test montelukast Reference singular®
Efficacy results summary
 As geometric means (ranged for) Cmax and AUCRatio
  Cmax (ng/mL) 428.910 381.900
176.680 783.900 80.000 792.150
  AUC0→Last (ng h/mL) 2731.650 2437.870
1386.330 6884.470 682.170 7495.260
  AUC0→inf (ng h/mL) 2825.270 2526.380
1445.510 7597.020 737.910 7963.160
 As medians (ranges) for Tmax, and t1/2
  Tmax (h) 3.50 3.50
2.00 6.00 1.50 5.00
  t1/2 (h) 4.10 4.49
2.42 6.36 2.20 5.71
Parameter Point estimate (ratio of geometric mean %) Lower limit % Upper limit % CV %
Bioequivalence results summary
 Cmax 112.169 101.447 124.024 23.58660
 AUC0→Last 111.939 101.285 123.714 23.47754
 AUC0→inf 111.711 101.119 123.413 23.38104