The role of IL-33 and mast cells in allergy and inflammation

Table 2 IL-33 mediated downstream signaling cascade

Cytokine	Downstream signaling cascade	Cell type	Functional effect	References
IL-33	MyD88	BMMCs	Survival of BMMCs	[74]
IL-33	MyD88	BMMCs	Production of cytokine e.g. IL-6 and IL-13	[75]
IL-33	MyD88	BMMCs	Proliferation of mast cell	[45]
IL-33	MyD88	BMMCs	Release of IL-6 and IL-13	[74]
IL-33	MyD88	Intestine (mice)	Production of type 2 cytokine e.g. IL-4, IL-5 and IL-13	[76]
IL-33	MyD88	Lungs (mice)	Goblet cell hyperplasia	[77]
IL-33	p38 MAPK	BMMCs	Proliferation of mast cell	[45]
IL-33	p38 MAPK	BMMCs	IL-6 release	[46]
IL-33	p38 MAPK	BMMCs	IL-6 and IL-13 release	[74]
IL-33	JNK, ERK, p38 MAPK, NFκB	BMMCs	IL-6 and IL-13 release	[78]
IL-33	NF-κB and JNK1/2, ERK1/2, and p38 MAPK	BMMCs	Production of IL-4, IL-5, IL-13, CCL2, CCL17, and CCL24	[5]
IL-33	p38 MAPK	Human mast cell LAD2	IL-13 release	[79]
IL-33	p38MAPK	Human umbilical cord blood-derived mast cells (HUCBMCs)	IL-8 release	[49]

ISSN: 2045-7022