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Table 2 IL-33 mediated downstream signaling cascade

From: The role of IL-33 and mast cells in allergy and inflammation

Cytokine Downstream signaling cascade Cell type Functional effect References
IL-33 MyD88 BMMCs Survival of BMMCs [74]
IL-33 MyD88 BMMCs Production of cytokine e.g. IL-6 and IL-13 [75]
IL-33 MyD88 BMMCs Proliferation of mast cell [45]
IL-33 MyD88 BMMCs Release of IL-6 and IL-13 [74]
IL-33 MyD88 Intestine (mice) Production of type 2 cytokine e.g. IL-4, IL-5 and IL-13 [76]
IL-33 MyD88 Lungs (mice) Goblet cell hyperplasia [77]
IL-33 p38 MAPK BMMCs Proliferation of mast cell [45]
IL-33 p38 MAPK BMMCs IL-6 release [46]
IL-33 p38 MAPK BMMCs IL-6 and IL-13 release [74]
IL-33 JNK, ERK, p38 MAPK, NFκB BMMCs IL-6 and IL-13 release [78]
IL-33 NF-κB and JNK1/2, ERK1/2, and p38 MAPK BMMCs Production of IL-4, IL-5, IL-13, CCL2, CCL17, and CCL24 [5]
IL-33 p38 MAPK Human mast cell LAD2 IL-13 release [79]
IL-33 p38MAPK Human umbilical cord blood-derived mast cells (HUCBMCs) IL-8 release [49]