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Table 1 Summary of allergological investigations (n = 29)

From: Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study

Participant

Age

Gender

Prick test

ImmunoCAP

CAST

ImmunoBlot

Symptoms after wine consumption

Further self-reported intolerances

Solvent

10 mg/ml Histamine

Rhinehessen Dornfelder

Rhinehessen Riesling

Moselle Pinot gris

Moselle Pinot noir

Moselle Riesling

red grape

white grape

red grape juice

total IgE [kU/l]

f259 Grape [kU/l]

CAP class

1

58

m

no prick test

53.2

0

0

/

-

D, R, SC, T

histamine intolerance

2

39

m

−/−

5/10

−/−

−/−

4/12

2/2

4/12

3/6

−/−

−/−

192

0.01

0

neg

-

R, AS

pollen, house-dust, apple, wine, cats

3

56

f

1/2

8/30

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

314

0.02

0

/

-

BS, SW

house-dust, drugs, nuts, grape, wine

4

60

f

−/−

5/7

5/6

1/2

2/3

2/2

5/7

0/1

0/1

2/3

5.38

0

0

neg

-

I, F, SR, D

drugs

5

35

m

−/−

5/8

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

286

0.05

0

neg

-

SW

house-dust

6

41

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

22

0

0

neg

-

AS, H

lactose, pollen, grass, rye

7

23

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

3/3

1/1

−/−

910

1.26

2

pos

+++

I, SR, H

pollen, house-dust, strawberries, apple, plum, peach,kiwi, carrot, wine

8

60

f

−/−

+++

+

+

+

−/−

+

−/−

−/−

+

10.4

0

0

neg

-

H

pollen, grapes, wine

9

42

f

−/−

5/15

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

10.6

0

0

/

-

V, D, SC, BP, CC, H

nickel

10

58

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

222

0.02

0

neg

-

R, H

alcohol, wine, beer

11

41

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

10.7

0.01

0

neg

-

n.d.

n.d.

12

54

f

−/−

10/30

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

11.9

0.03

0

/

-

R, BS, H

/

13

24

f

no prick test

189

0.01

0

pos

-

I, F

pollen

14

30

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

74.3

0

0

neg

-

D, T, H

/

15

30

f

−/−

10/15

−/−

−/−

−/−

−/−

−/−

−/−

−/−

+

109

0.05

0

pos

-

I, R

pollen, house-dust, nuts, kiwi, sweet pepper, seafood

16

50

f

−/−

10/30

2/3

2/3

2/3

3/5

3/4

2/3

1

8/15

359

0.01

0

neg

-

n.d.

wine

17

41

f

−/−

++

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

6.91

0.02

0

neg

-

F, D, SC, H

wine

18

28

f

−/−

6/22

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

214

0

0

neg

/

D

fructose intolerance, house-dust

19

24

m

−/−

5/25

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

95.4

0

0

pos

/

SR, H

pollen

20

45

f

no prick test

108

0

0

neg

/

/

pollen, house-dust, oysters

21

34

f

−/−

++

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

16.1

0

0

neg

-

/

/

22

63

m

−/−

++

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

622

0.05

0

neg

-

/

canned mushrooms

23

30

f

−/−

5/25

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

2.58

0

0

neg

+

/

/

24

60

f

−/−

7/20

−/−

−/−

−/−

−/−

−/−

2/4

3/5

−/−

40.7

0

0

pos

/

/

pollen, nuts, apple

25

29

f

−/−

6/25

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

35.7

0

0

neg

/

/

pollen

26

27

f

−/−

5/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

12.1

0

0

neg

/

H

/

27

28

m

−/−

3/15

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

109

0

0

neg

/

/

/

28

22

f

−/−

8/20

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

114

0

0

neg

/

/

/

29

28

f

−/−

7/22

−/−

−/−

−/−

−/−

−/−

−/−

−/−

−/−

90.5

0

0

neg

/

/

/

  1. Subject group with self-reported wine intolerance: No.1–19 control group: No. 20–29; m male; f female; neg negativ; pos positiv; +++ large reaction (size of histamine reaction); ++: normal reaction, +: weak reaction; −: no reaction (wheal diameter < 2 mm); /: no test performed; CAP classes for specific IgE antibodies: 0: < 0.35kU/l; 1: 0.35–0.7 kU/l: 2: 0.7–3.5 kU/l; 3: 3.5–17.5 kU/l; 4: 17.5–50 kU/l; 5: 50–100 kU/l; 6: >100 kU/l; n.d. no data; H headaches; D diarrhea; R rhinorrhea; I itching; F flushed skin; SR skin rash, hives, edema; SC stomach or intestinal cramps; BS burning sensation in lips, palate, neck; SW swelling of lips, mouth, throat; AS shortness of breath/asthma; T tachycardia; V vomiting; BP low blood pressure; CC circulatory collapse. Prick test results are given in wheal diameter/ flush diameter, in mm (x/y). Moselle Riesling: Bernkasteller Badstube, Staatsweingut Mosel, Bernkastel-Kues, Germany, 2009, 11 %vol; Moselle Pinot gris: Grauburgunder, Staatliche Weinbaudomäne Trier, Germany, 12,5 %vol, 2009; Moselle Pinot noir: Avelsbacher Hammerstein Spätburgunder, Staatliche Weinbaudomäne Trier, Germany, 12 %vol, 2009; Rhinehessen Riesling: Riesling, Winery of the City of Mainz, Mainz, Germany, 12,5 %vol, 2009; Rhinehessen Dornfelder: Dornfelder, Winery of the City of Mainz, Mainz, Germany, 13,5 %vol, 2009