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Table 1 Summary of allergological investigations (n = 29)

From: Assessment of sensitization to grape and wine allergens as possible causes of adverse reactions to wine: a pilot study

Participant Age Gender Prick test ImmunoCAP CAST ImmunoBlot Symptoms after wine consumption Further self-reported intolerances
Solvent 10 mg/ml Histamine Rhinehessen Dornfelder Rhinehessen Riesling Moselle Pinot gris Moselle Pinot noir Moselle Riesling red grape white grape red grape juice total IgE [kU/l] f259 Grape [kU/l] CAP class
1 58 m no prick test 53.2 0 0 / - D, R, SC, T histamine intolerance
2 39 m −/− 5/10 −/− −/− 4/12 2/2 4/12 3/6 −/− −/− 192 0.01 0 neg - R, AS pollen, house-dust, apple, wine, cats
3 56 f 1/2 8/30 −/− −/− −/− −/− −/− −/− −/− −/− 314 0.02 0 / - BS, SW house-dust, drugs, nuts, grape, wine
4 60 f −/− 5/7 5/6 1/2 2/3 2/2 5/7 0/1 0/1 2/3 5.38 0 0 neg - I, F, SR, D drugs
5 35 m −/− 5/8 −/− −/− −/− −/− −/− −/− −/− −/− 286 0.05 0 neg - SW house-dust
6 41 f −/− 5/20 −/− −/− −/− −/− −/− −/− −/− −/− 22 0 0 neg - AS, H lactose, pollen, grass, rye
7 23 f −/− 5/20 −/− −/− −/− −/− −/− 3/3 1/1 −/− 910 1.26 2 pos +++ I, SR, H pollen, house-dust, strawberries, apple, plum, peach,kiwi, carrot, wine
8 60 f −/− +++ + + + −/− + −/− −/− + 10.4 0 0 neg - H pollen, grapes, wine
9 42 f −/− 5/15 −/− −/− −/− −/− −/− −/− −/− −/− 10.6 0 0 / - V, D, SC, BP, CC, H nickel
10 58 f −/− 5/20 −/− −/− −/− −/− −/− −/− −/− −/− 222 0.02 0 neg - R, H alcohol, wine, beer
11 41 f −/− 5/20 −/− −/− −/− −/− −/− −/− −/− −/− 10.7 0.01 0 neg - n.d. n.d.
12 54 f −/− 10/30 −/− −/− −/− −/− −/− −/− −/− −/− 11.9 0.03 0 / - R, BS, H /
13 24 f no prick test 189 0.01 0 pos - I, F pollen
14 30 f −/− 5/20 −/− −/− −/− −/− −/− −/− −/− −/− 74.3 0 0 neg - D, T, H /
15 30 f −/− 10/15 −/− −/− −/− −/− −/− −/− −/− + 109 0.05 0 pos - I, R pollen, house-dust, nuts, kiwi, sweet pepper, seafood
16 50 f −/− 10/30 2/3 2/3 2/3 3/5 3/4 2/3 1 8/15 359 0.01 0 neg - n.d. wine
17 41 f −/− ++ −/− −/− −/− −/− −/− −/− −/− −/− 6.91 0.02 0 neg - F, D, SC, H wine
18 28 f −/− 6/22 −/− −/− −/− −/− −/− −/− −/− −/− 214 0 0 neg / D fructose intolerance, house-dust
19 24 m −/− 5/25 −/− −/− −/− −/− −/− −/− −/− −/− 95.4 0 0 pos / SR, H pollen
20 45 f no prick test 108 0 0 neg / / pollen, house-dust, oysters
21 34 f −/− ++ −/− −/− −/− −/− −/− −/− −/− −/− 16.1 0 0 neg - / /
22 63 m −/− ++ −/− −/− −/− −/− −/− −/− −/− −/− 622 0.05 0 neg - / canned mushrooms
23 30 f −/− 5/25 −/− −/− −/− −/− −/− −/− −/− −/− 2.58 0 0 neg + / /
24 60 f −/− 7/20 −/− −/− −/− −/− −/− 2/4 3/5 −/− 40.7 0 0 pos / / pollen, nuts, apple
25 29 f −/− 6/25 −/− −/− −/− −/− −/− −/− −/− −/− 35.7 0 0 neg / / pollen
26 27 f −/− 5/20 −/− −/− −/− −/− −/− −/− −/− −/− 12.1 0 0 neg / H /
27 28 m −/− 3/15 −/− −/− −/− −/− −/− −/− −/− −/− 109 0 0 neg / / /
28 22 f −/− 8/20 −/− −/− −/− −/− −/− −/− −/− −/− 114 0 0 neg / / /
29 28 f −/− 7/22 −/− −/− −/− −/− −/− −/− −/− −/− 90.5 0 0 neg / / /
  1. Subject group with self-reported wine intolerance: No.1–19 control group: No. 20–29; m male; f female; neg negativ; pos positiv; +++ large reaction (size of histamine reaction); ++: normal reaction, +: weak reaction; −: no reaction (wheal diameter < 2 mm); /: no test performed; CAP classes for specific IgE antibodies: 0: < 0.35kU/l; 1: 0.35–0.7 kU/l: 2: 0.7–3.5 kU/l; 3: 3.5–17.5 kU/l; 4: 17.5–50 kU/l; 5: 50–100 kU/l; 6: >100 kU/l; n.d. no data; H headaches; D diarrhea; R rhinorrhea; I itching; F flushed skin; SR skin rash, hives, edema; SC stomach or intestinal cramps; BS burning sensation in lips, palate, neck; SW swelling of lips, mouth, throat; AS shortness of breath/asthma; T tachycardia; V vomiting; BP low blood pressure; CC circulatory collapse. Prick test results are given in wheal diameter/ flush diameter, in mm (x/y). Moselle Riesling: Bernkasteller Badstube, Staatsweingut Mosel, Bernkastel-Kues, Germany, 2009, 11 %vol; Moselle Pinot gris: Grauburgunder, Staatliche Weinbaudomäne Trier, Germany, 12,5 %vol, 2009; Moselle Pinot noir: Avelsbacher Hammerstein Spätburgunder, Staatliche Weinbaudomäne Trier, Germany, 12 %vol, 2009; Rhinehessen Riesling: Riesling, Winery of the City of Mainz, Mainz, Germany, 12,5 %vol, 2009; Rhinehessen Dornfelder: Dornfelder, Winery of the City of Mainz, Mainz, Germany, 13,5 %vol, 2009
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