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Table 2 Children who underwent a mixed nut challenge

From: Usefulness of open mixed nut challenges to exclude tree nut allergy in children

Case Age (yrs) Reason for long elimination diet Mix Max dose (g)* Symptoms Outcome Conclusion & advice Pre diet Post diet sIgE Grass sIgE Birch sIgE Haz sIgE Alm sIgE Cas sIgE Pis sIgE Bra sIgE Pec sIgE Wal
1 6,5 Multiple sensitization and peanut allergy A 6,7 Aversion with OAS, abdominal pain, vomiting +/− Tree nut allergy, multiple challenges No nuts No nuts 0,5 1,5 13,1 1,1 3,0 1,2 0,4 0,6 0,4
2 6,6 Multiple sensitization and reaction to 1 nut (Cas S2) B 13,3 Aversion +/− Suspected cas/pis allergy introduction of alm, bra, pec, wal Alm Alm, bra, pec, wal1 0,2 0,0 0,9 0,0 1,1 0,2 0,0 0,0 0,0
3 15,2 Multiple sensitization and eczema A 20,1 Rhino-conjunctivitis + Suspected tree nut allergy, introduction of alm, bra, pec No nuts Alm, bra, pec1 10,4 76,0 21,8 0,3 1,2 2,1 0,1 0,3 7,1
4 9,7 Multiple sensitization and peanut allergy A 6,7 Rash, urticaria, conjunctivitis, sensation of throat tightness, abdominal pain + Tree nut allergy, multiple challenges No nuts Alm, wal2 19,6 37,0 15,5 2,7 7,9 7,8 1,5 0,3 1,2
5 9,4 Multiple sensitization and other food allergy A 2,2 OAS, rhino-conjunctivitis, vomiting + Tree nut allergy, multiple challenges No nuts No nuts 50,0 101,0 74,0 0,4 2,7 4,1 0,2 0,3 0,3
6 5,4 Multiple sensitization and other food allergy A 6,7 Rash, rhino-conjunctivitis, angioedema, vomiting + Tree nut allergy, multiple challenges Alm Alm 1,7 5,0 2,3 0,2 2,3 3,3 0,0 0,5 0,6
7 8 Multiple sensitization and other food allergy A    - Introduction all nuts Alm None 37,0 73,0 32,8 0,5 0,0 0,0 0,1 0,1 0,0
8 11,4 Multiple sensitization and reaction to 1 nut (Pis S5) B    - Introduction tested nuts Ntn No nuts3 0,0 0,0 2,0 0,6 12,0 23,7 0,4 0,7 2,9
9 6,3 Multiple sensitization and other food allergy B    - Introduction tested nuts Ntn No nuts4 14,1 101,0 19,7 0,3 7,3 10,8 0,0 0,8 2,8
10 15,4 Multiple sensitization and peanut allergy A    - Introduction all nuts Ntn No nuts5 101,0 43,0 8,5 2,4 0,4 0,6 0,1 0,9 1,9
11 10 Multiple sensitization and peanut allergy A    - Introduction all nuts No nuts None 7,9 2,3 2,3 2,5 1,1 1,6 1,0 1,8 2,1
12 9 Multiple sensitization and peanut allergy A    - Introduction all nuts No nuts None 56,0 101,0 87,0 7,0 1,2 1,0 0,9 0,7 0,3
13 9,8 Multiple sensitization and eczema A    - Introduction all nuts No nuts None 11,3 1,4 0,5 0,3 0,3 0,6 0,2 0,2 0,2
14 9,7 Multiple sensitization and peanut allergy A    - Introduction all nuts No nuts None 101,0 101,0 101,0 7,4 1,6 2,5 1,2 2,9 2,6
15 8 Multiple sensitization and eczema A    - Introduction all nuts No nuts No nuts6 19,0 17,8 8,6 0,3 0,8 1,0 0,4 0,0 0,1
16 17,1 Multiple sensitization and peanut allergy A    - Introduction all nuts Ntn None 16,0 36,0 27,9 2,3 1,8 1,2 1,1 0,2 0,4
17 14,1 Multiple sensitization and other food allergy A    - Introduction all nuts No nuts None 4,4 13,2 7,2 0,3 0,1 0,2 0,1 0,2 0,3
18 10 Multiple sensitization and peanut allergy A    - Introduction all nuts Ntn None 17,3 28,3 18.90 1,4 0,6 0,8 0,4 0,1 0,1
19 12,5 Multiple sensitization and peanut allergy B    - Introduction tested nuts No nuts No nuts4 30,0 101,0 3.50 1,0 17,4 20,7 0,5 1,2 2,1
  1. Alm, almond; Bra, Brazil nut; Cas, cashew nut; Haz, hazelnut; Ntn, no traces of nuts; Pec, pecan; Pis, pistachio; Wal, walnut
  2. * Maximum dose in total grams mixed tree nuts
  3. +, positive; −, negative; +/−, inconclusive
  4. 1Introduction started based on negative sIgE results
  5. 2Introduction started by parents
  6. 3Introduction not started due to comorbidities of the child
  7. 4Introduction successful but preventive nut free diet due to possible cashew or pistachio allergy
  8. 5Oral allergy symptoms after whole nuts
  9. 6Introduction not started, parents are used to diet due to other food allergies