Antigen-induced airway obstruction and responsiveness in sensitised guinea pigs. A) Average of maximum broncho-obstructive index (Rmax) induced by ovalbumin (closed squares) and saline (open squares) challenges in sensitised guinea pigs. B) PD200 ratio corresponds to PD200 value observed after antigen challenge divided by PD200 value before challenge. Bars represent mean ± SEM (n = 7 per group). *P < 0.05 compared with control (repeated measures ANOVA with Dunnett’s multiple comparisons test). +
P < 0.05 compared with control (unpaired Student’s t-test).