Heterogeneous responses and cross reactivity between the major peanut allergens Ara h 1, 2,3 and 6 in a mouse model for peanut allergy

Table 1 Summary of PE, Ara h 1, 2, 3 and 6 specific IgE and T cell responses in vivo (Figures 1 and 2 )

Specific IgE
→ IgE
↓ sensitization	PE	Ara h 1	Ara h 2	Ara h 3	Ara h 6
PE	+++	+++	++	++	++
Ara h 1	++	+++	+	+	+
Ara h 2	+	+	++	+	++
Ara h 3	+	+	+	++	+
Ara h 6	++	+	+	+	++
Spleen T cell responses (IL-5 and IL-13)
→ restim.
↓ sensitization	PE	Ara h 1	Ara h 2	Ara h 3	Ara h 6
PE	+++	++	+/−	++	++
Ara h 1	++	++	-	+	+
Ara h 2	+	-, +(IL-13)	+/−	+	+
Ara h 3	+	-, +(IL-13)	-	++	+
Ara h 6	++	+	-, +/−(IL-13)	+	++

ISSN: 2045-7022