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Table 5 Characteristics of 39 patients with positive OPTs according to the Caimmi classification [16]

From: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Time of reaction

Clinical manifestation

Type of reaction

Underlying disease

Putative mechanism

Patients n = 38*

Acute (immediate to several hours after exposure)

Rhinitis-asthma and/or urticaria-angioedema

Cross-reactive

Asthma/rhinosinuitis and/or chronic urticaria

Inhibition of COX-1

23

Urticaria/angioedema and/or rhinoconjunctivitis

Multiple NSAIDs induced

No underlying chronic disease or atopy or rhinoconjunctivitis

Unknown, presumably related to COX-1 inhibition

6

Urticaria/angioedema/anaphylaxis

Single drug induced

Atopy or food allergy or drug allergy

IgE-mediated

9

Delayed (more than 6 h after exposure)

Fixed drug eruptions, severe bullous skin reaction, maculopapular drug eruptions, pneumonitis, aseptic meningitis, nephritis, contact and photo-contact dermatitis

Single drug or multiple drug induced

Usually no

T-cell mediated (type IV) Cytotoxic T cells NK cells Other

0

  1. *1 patient could not be classified.