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Table 5 Characteristics of 39 patients with positive OPTs according to the Caimmi classification [16]

From: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Time of reaction Clinical manifestation Type of reaction Underlying disease Putative mechanism Patients n = 38*
Acute (immediate to several hours after exposure) Rhinitis-asthma and/or urticaria-angioedema Cross-reactive Asthma/rhinosinuitis and/or chronic urticaria Inhibition of COX-1 23
Urticaria/angioedema and/or rhinoconjunctivitis Multiple NSAIDs induced No underlying chronic disease or atopy or rhinoconjunctivitis Unknown, presumably related to COX-1 inhibition 6
Urticaria/angioedema/anaphylaxis Single drug induced Atopy or food allergy or drug allergy IgE-mediated 9
Delayed (more than 6 h after exposure) Fixed drug eruptions, severe bullous skin reaction, maculopapular drug eruptions, pneumonitis, aseptic meningitis, nephritis, contact and photo-contact dermatitis Single drug or multiple drug induced Usually no T-cell mediated (type IV) Cytotoxic T cells NK cells Other 0
  1. *1 patient could not be classified.