Time of reaction | Clinical manifestation | Type of reaction | Underlying disease | Putative mechanism | Patients n = 38* |
---|---|---|---|---|---|
Acute (immediate to several hours after exposure) | Rhinitis-asthma and/or urticaria-angioedema | Cross-reactive | Asthma/rhinosinuitis and/or chronic urticaria | Inhibition of COX-1 | 23 |
Urticaria/angioedema and/or rhinoconjunctivitis | Multiple NSAIDs induced | No underlying chronic disease or atopy or rhinoconjunctivitis | Unknown, presumably related to COX-1 inhibition | 6 | |
Urticaria/angioedema/anaphylaxis | Single drug induced | Atopy or food allergy or drug allergy | IgE-mediated | 9 | |
Delayed (more than 6Â h after exposure) | Fixed drug eruptions, severe bullous skin reaction, maculopapular drug eruptions, pneumonitis, aseptic meningitis, nephritis, contact and photo-contact dermatitis | Single drug or multiple drug induced | Usually no | T-cell mediated (type IV) Cytotoxic T cells NK cells Other | 0 |