Skip to main content

Table 4 Characteristics of 39 patients with positive OPT according to the EAACI/ENDA classification [12]

From: Hypersensitivity to non-steroidal anti-inflammatory drugs (NSAIDs): classification of a Danish patient cohort according to EAACI/ENDA guidelines

Type of reaction Clinical manifestation Timing of reaction Underlying disease Cross-reactivity Putative mechanism Patients n = 38*
NSAIDs-exacerbated respitoratory disease (NERD) Bronchial obstruction, dyspnea and/or nasal congestion/rhinorrhea Acute (usually immediate to several hours after exposure) Asthma/rhinosinuitis/nasal polyps Cross-reactive Non-allergic COX-1 Inhibition 9
NSAIDs-exacerbated cutaneous disease (NECD) Wheals and/or angioedema Chronic urticaria Cross-reactive Non-allergic COX-1 Inhibition 14
NSAIDs-induced urticaria/angioedema (NIUA) Wheals and/or angioedema No underlying chronic diseases Cross-reactive Non-allergic Unknown, probably COX-1 inhibition 6
Single NSAID-induced urticaria/angioedema and anaphylaxis (SNIUAA) Wheals/angioedema/anaphylaxis No underlying chronic diseases Single drug induced Allergic IgE-mediated 9
Single-NSAID-induced delayed reactions (SNIDR) Various symptoms and organs involved (e.g., fixed drug eruption, SJS/TEN, nephritis) Delayed onset (usually more than 24 h after exposure) No underlying chronic diseases Single drug or multiple drug induced Allergic T-cell mediated 0
  1. *1 patient could not be classified.