Skip to main content

Advertisement

Table 4 Univariate association of symptoms during challenge with observer agreement, n =191

From: Standardized food challenges are subject to variability in interpretation of clinical symptoms

Tract Symptoms Disagree (n =59) Agree (n =132) p
Upper airways Red/itchy eyes 10 (17) 13 (10) 0.168
Sneezing 10 (17) 10 (8) 0.056
Nasal congestion/rhinorrhoea - 10 (8) 0.043*
Lower airways Cough 5 (9) 6 (5) 0.282
Hoarseness/difficulty swallowing - 3 (2) 0.243
In- and/or expiratory stridor - 5 (4) 0.130
Wheezing - 4 (3) 0.177
Dyspnoea 3 (5) 2 (2) 0.153
Gastro-intestinal OAS^ 28 (48) 12 (9) 0.000**
Abdominal complaints^ 21 (36) 6 (5) 0.000**
Vomiting 4 (7) 5 (4) 0.374
Diarrhoea - - -
Skin Contact urticaria# 9 (15) 13 (9) 0.283
Redness 12 (20) 9 (7) 0.008**
Pruritis 4 (7) 6 (5) 0.525
Urticaria - 10 (8) 0.043*
Angioedema - 2 (2) 0.342
Neurological Change in activity level/loss of consciousness - - -
Other subjective signs Discomfort^ 2 (3) 10 (8) 0.283
Food aversion^ 14 (24) 10 (8) 0.003**
Number of different objective symptoms No objective symptoms 18 (32) 2 (4) Ref
1 symptom 22 (39) 23 (40) 0.005**
2 symptoms 13 (23) 22 (40) 0.001**
3 symptoms 3 (5) 8 (15) 0.002**
  1. OAS, Oral Allergy Symptoms; Ref, Reference category.
  2. ^ Symptoms referred to as subjective symptoms.
  3. #Local urticaria after direct contact between the challenge material and skin.
  4. * Statistical significant association with agreement.
  5. **Statistical significant association with disagreement.
  6. Bold numbers are statistically significant (p <0.05).