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Table 4 Univariate association of symptoms during challenge with observer agreement, n =191

From: Standardized food challenges are subject to variability in interpretation of clinical symptoms

Tract

Symptoms

Disagree (n =59)

Agree (n =132)

p

Upper airways

Red/itchy eyes

10 (17)

13 (10)

0.168

Sneezing

10 (17)

10 (8)

0.056

Nasal congestion/rhinorrhoea

-

10 (8)

0.043*

Lower airways

Cough

5 (9)

6 (5)

0.282

Hoarseness/difficulty swallowing

-

3 (2)

0.243

In- and/or expiratory stridor

-

5 (4)

0.130

Wheezing

-

4 (3)

0.177

Dyspnoea

3 (5)

2 (2)

0.153

Gastro-intestinal

OAS^

28 (48)

12 (9)

0.000**

Abdominal complaints^

21 (36)

6 (5)

0.000**

Vomiting

4 (7)

5 (4)

0.374

Diarrhoea

-

-

-

Skin

Contact urticaria#

9 (15)

13 (9)

0.283

Redness

12 (20)

9 (7)

0.008**

Pruritis

4 (7)

6 (5)

0.525

Urticaria

-

10 (8)

0.043*

Angioedema

-

2 (2)

0.342

Neurological

Change in activity level/loss of consciousness

-

-

-

Other subjective signs

Discomfort^

2 (3)

10 (8)

0.283

Food aversion^

14 (24)

10 (8)

0.003**

Number of different objective symptoms

No objective symptoms

18 (32)

2 (4)

Ref

1 symptom

22 (39)

23 (40)

0.005**

2 symptoms

13 (23)

22 (40)

0.001**

3 symptoms

3 (5)

8 (15)

0.002**

  1. OAS, Oral Allergy Symptoms; Ref, Reference category.
  2. ^ Symptoms referred to as subjective symptoms.
  3. #Local urticaria after direct contact between the challenge material and skin.
  4. * Statistical significant association with agreement.
  5. **Statistical significant association with disagreement.
  6. Bold numbers are statistically significant (p <0.05).