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O06 - The Chelsea, asthma and fresh fruit intake in children (CHAFFINCH) trial – pilot study
Clinical and Translational Allergy volume 4, Article number: O6 (2014)
Observational evidence suggests that intake of fruits, and of dietary antioxidants would be protective against symptoms and severity of asthma in children. Intervention studies with single or combined antioxidant supplements have so far been disappointing. To date, there have been no interventions using fresh fruit on asthmatic children. We plan to carry out a 3 month randomised controlled trial (RCT) in 360 children, to establish whether increasing fruit intake could be useful in the management of childhood asthma.
Objective of the Pilot
To assess recruitment strategy, follow-up, tolerance to respiratory and biomarker tests, and fruit intake compliance (FIC).
32 children aged 6 to 10 years old with mild to severe asthma were recruited and randomly allocated to one of the following fruit groups daily, for a month, in addition to their usual diet: 1) an apple, 2) a banana, 3) an apple and a banana, 4) control. Quality of life, lung function, and inflammation were measured with the Juniper Asthma Quality of Life Questionnaire (JAQoLQ), pre- and post- bronchodilator spirometry, and exhaled nitric oxide (eNO), respectively, at baseline and at follow-up. FIC was measured through a dietary questionnaire (DQ) and sticker charts. Urinary metabolomic analyses (UMA) were carried out to identify specific metabolites of fruit intake.
28 children (88%) completed all the tests at baseline and at follow-up. All children were able to perform satisfactory respiratory and eNO tests. Levels of eNO were 18% lower in groups 2 and 3 after the intervention. DQ and sticker charts were the best FIC methods, with a 96% adherence. UMA showed higher levels of polyphenol antioxidants after ingestion of fruits.
A RCT with fresh fruit is a feasible intervention in small children with various levels of asthma.
UK Clinical Research Governance Trial ID 11874. Funded by the BUPA Foundation.
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Garcia-Larsen, V., Bush, A., Boyle, R.J. et al. O06 - The Chelsea, asthma and fresh fruit intake in children (CHAFFINCH) trial – pilot study. Clin Transl Allergy 4, O6 (2014) doi:10.1186/2045-7022-4-S1-O6
- Nitric Oxide
- Severe Asthma
- Asthmatic Child