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Table 5 Sensitization (frequency and serum level) to food allergens of animal origin

From: Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis

Food allergen    Total n = 211 Mild/moderate AD n = 141 Severe AD n = 70 P-value n (%)1median2
Cow’s milk   n (%) 51 (24.2) 26 (18.4) 25 (35.7) 0.006*
  nBos d 4 n (%) 10 (4.7) 8 (5.7) 2 (2.9) n.r.
(α-lactalbu.) Median (IQR) 0.54 (0.32-2.63) 0.54 (0.31-2.37) 1.60 (0.40-x) 0.60
  nBos d 5 n (%) 10 (4.7) 6 (4.3) 4 (5.7) n.r.
(β-lactoglob.) Median (IQR) 1.44 (0.71-4.21) 0.89 (0.47-3.04) 2.59 (1.98-11.67) 0.06
nBos d 6 n (%) 11 (5.2) 6 (4.3) 5 (7.1) n.r.
(serum albu.) Median (IQR) 1.01 (0.53-4.04) 0.81 (0.52-5.58) 1.54 (0.59-5.89) 0.72
nBos d 8 n (%) 25 (11.8) 14 (9.9) 11 (15.7) 0.22
(casein) Median (IQR) 2.23 (1.11-5.89) 1.73 (0.80-4.75) 3.30 (1.27-8.69) 0.30
nBos d lactoferrin n (%) 34 (16.1) 16 (11.3) 18 (25.7) 0.008*
(transferrin) Median (IQR) 1.42 (0.68-2.45) 0.97 (0.50-2.05) 1.95 (1.12-2.92) 0.05
Hen’s egg   n (%) 28 (13.3) 16 (11.3) 12 (17.1) 0.24
  nGal d 1 n (%) 23 (10.9) 12 (8.5) 11 (15.7) 0.11
(ovomucoid) Median (IQR) 1.96 (0.63-5.19) 2.84 (1.24-5.36) 1.16 (0.46-5.19) 0.24
nGal d 2 n (%) 10 (4.7) 4 (2.8) 6 (8.6) n.r.
(ovalbumin) Median (IQR) 1.64 (0.51-3.64) 0.71 (0.42-4.69) 2.21 (1.05-6.63) 0.29
nGal d 3 n (%) 6 (2.8) 3 (2.1) 3 (4.3) n.r.
(ovotransfer.) Median (IQR) 1.08 (0.68-2.68) 0.78 (0.69-x) 2.04 (0.63-x) 0.51
nGal d 5 n (%) 4 (1.9) 0 (0) 4 (5.7) n.r.
(serum albu.) Median (IQR) 0.43 (0.31-094) - 0.43 (0.31-094) -
Fish   n (%) 24 (11.4) 12 (8.5) 12 (17.1) 0.06
  rCyp c 1 n (%) 23 (10.9) 12 (8.5) 11 (15.7) 0.11
(parvalb.) Median (IQR) 2.43 (0.50-15.0) 2.00 (0.45-8.80) 2.43 (0.50-21.78) 0.30
rGad c 1 n (%) 13 (6.2) 5 (3.5) 8 (11.4) n.r.
(parvalb.) Median (IQR) 4.96 (2.47-7.85) 5.80 (4.65-7.85) 3.71 (0.93-18.72) 0.24
Shrimp   n (%) 15 (7.1) 5 (3.5) 10 (14.3) n.r.
  rPen a 1 n (%) 8 (3.8) 2 (1.4) 6 (8.6) n.r.
(tropomyosin) Median (IQR) 10.18 (1.24-33.22) 28.44 (18.87-x) 3.85 (0.54-37.20) 0.18
nPen i 1 n (%) 11 (5.2) 4 (2.8) 7 (10.0) n.r.
(tropomyosin) Median (IQR) 5.33 (1.50-26.0) 11.08 (0.91-40.31) 5.33 (1.50-26.0) 0.85
nPen m 1 n(%) 13 (6.2) 4 (2.8) 9 (12.9) n.r.
(tropomyosin) Median (IQR) 5.14 (0.48-30.46) 11.24 (0.39-43.73) 5.14 (0.70-23.89) > 0.99
Total 3   n (%) 75 (35.5) 39 (27.7) 36 (51.4) 0.001*
  1. 1Chi-square; mild/moderate versus severe AD. *p < 0.01.; 2Mann–Whitney U-test; mild/moderate versus severe AD.
  2. 3Frequency of sensitization to any of the animal allergens. n.r, non-reliable, due to small number.