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Table 3 Sensitization (frequency and serum level) to food allergens of plant origin: selection of food allergens most relevant in the Dutch population

From: Food allergen sensitization pattern in adults in relation to severity of atopic dermatitis

Food Allergen   Total n = 211 Mild/moderate AD n = 141 Severe AD n = 70 P-value n (%)1median2
Kiwi   n (%) 76 (36.0) 44 (31.2) 32 (45.7) 0.04
  nAct d 1 n (%) 24 (11.4) 11 (7.8) 13 (18.6) 0.02
(cyst. protease) Median (IQR) 1.83 (0.49-10.95) 2.10 (1.06-11.32) 0.71 (0.36-13.39) 0.28
  nAct d 2 n (%) 25 (11.8) 17 (12.1) 8 (11.4) 0.89
(TLP) Median (IQR) 1.92 (1.08-3.23) 1.92 (1.49-3.44) 1.36 (0.82-3.19) 0.29
  nAct d 5 n (%) 1 (0.5) 0 (0) 1 (1.4) n.r.
(Kiwellin) Median (IQR) 0.62 (0.62-0.62) - 0.62 (0.62-0.62) n.r.
  nAct d 8 n (%) 44 (20.9) 27 (19.1) 17 (24.3) 0.39
(PR-10) Median (IQR) 1.93 (0.76-7.17) 1.83 (0.74-3.93) 2.52 (1.12-10.81) 0.16
Peanut   n (%) 119 (56.4) 74 (52.5) 45 (64.3) 0.10
  nAra h 1 n (%) 24 (11.4) 9 (6.4) 15 (21.4) 0.001*
(SP) Median (IQR) 6.78 (1.45-11.83) 7.70 (3.93-17.16) 4.62 (0.95-12.09) 0.46
  nAra h 2 n (%) 23 (10.9) 14 (9.9) 9 (12.9) 0.52
(SP) Median (IQR) 15.78 (5.55-35.6) 11.41 (4.89-33.30) 32.69 (8.18-56.05) 0.31
  nAra h 3 n (%) 16 (7.6) 7 (5.0) 9 (12.9) 0.04
(SP) Median (IQR) 4.82 (1.0-22.66) 1.61 (0.88-42.95) 5.60 (1.33-22.26) 0.79
  rAra h 8 n (%) 112 (53.1) 70 (49.6) 42 (60.0) 0.16
(PR-10) Median (IQR) 4.73 (1.66-13.02) 3.76 (1.57-9.18) 8.81 (1.85-16.16) 0.08
Hazelnut   n (%) 120 (56.9) 78 (55.3) 42 (60.0) 0.52
  rCor a 1.0401 n (%) 117 (55.5) 76 (53.9) 41 (58.6) 0.52
(PR-10) Median (IQR) 5.29 (2.30-12.37) 4.76 (2.18-12.0) 5.63 (2.38-16.03) 0.50
  rCor a 8 n (%) 11 (5.2) 7 (5.0) 4 (5.7) n.r.
(LTP) Median (IQR) 2.78 (0.50-5.49) 2.94 (0.85-5.49) 0.81 (0.37-28.58) 0.35
  nCor a 9 n (%) 12 (5.7) 9 (6.4) 3 (4.3) n.r.
(SP) Median (IQR) 1.49 (0.69-1.60) 1.50 (0.98-1.60) 0.60 (0.49-x) 0.64
Apple rMal d 1 n (%) 126 (59.7) 81 (57.4) 45 (64.3) 0.34
(PR-10) Median (IQR) 12.35 (4.50-36.50) 10.00 (3.76-29.2) 24.02 (5.35-51.38) 0.06
Peach   n (%) 122 (57.8) 81 (57.4) 41 (58.6) 0.88
  rPru p 1 n (%) 121 (57.3) 80 (56.7) 41 (58.6) 0.80
(PR-10) Median (IQR) 9.08 (2.73-20.78) 6.85 (2.33-13.11) 11.00 (4.18-30.61) 0.02
  nPru p 3 n (%) 11 (5.2) 8 (5.7) 3 (4.3) n.r.
(LTP) Median (IQR) 4.40 (2.02-7.21) 4.70 (1.88-6.95) 2.70 (2.02-x) > 0.99
Tree PR-10   n (%) 137 (64.9) 91 (64.5) 46 (65.7) 0.87
  rBet v 1 n (%) 136 (64.5) 90 (63.8) 46 (65.7) 0.79
Median (IQR) 34.97 (11.29-80.86) 32.95 (9.36-57.11) 48.5 (17.86-116.25) 0.009*
rAln g 1 n (%) 129 (61.1) 84 (59.6) 45 (64.3) 0.51
Median (IQR) 13.52 (3.37-31.13) 10.25 (3.21-29.70) 14.89 (4.42-32.04) 0.33
rCor a 1.0101 n (%) 118 (55.9) 76 (53.9) 42 (60.0) 0.40
Median (IQR) 7.00 (2.45-20.83) 7.35 (3.14-20.57) 12.50 (6.09 -22.90) 0.13
Total PR-10   n (%) 134 (63.5) 88 (62.4) 46 (65.7) 0.64
  1. 1Chi-square; mild/moderate versus severe AD; 2Mann–Whitney U-test; mild/moderate versus severe AD. *p < 0.01; n.r, non-reliable, due to small number; PR-10 protein Bet v1 homulogus; SP: storage protein; LTP: lipid transfer protein; TLP: Thaumatin-like protein.