Table 1 Characteristics of pediatric patients with gastrointestinal symptoms suggestive of non-IgE cow’s milk allergy
All patients | Challenge negative | Challenge positive | p-value* | Controls (with no food allergies) | |
|---|---|---|---|---|---|
n = 57 | n = 39 | n = 18 | n = 22 | ||
Age, months (median, range) | 8.7 (2.4–40.8) | 8.7 (2.5 –25.6) | 8.4 (2.4–40.8) | NS | 13.2 (4.8–30) |
Duration of CM free diet before challenge, months (median, range) | 2.5 (0.5–35) | 2.4 (0.5–14) | 2.5 (0.5–35) | NS | NA |
CM specifig IgE > 0.35 kU/l | 0 | 0 | 0 | NS | 0 |
SPT wheal size ≥3 mm for cow’s milk | 4 | 2 | 2 | NS | ND |
Symptoms associated with CMA suspicion | |||||
Loose stools, n (%) | 18 (46%) | 14 (78%) | 0.0432 | ||
During CM challenge | 1 | 15 | 0.0001 | ||
Placebo challenge | 10 | 1 | |||
Excessive crying, n (%) | 30 (77%) | 11 (56%) | NS | ||
During CM challenge | 2 | 8 | NS | ||
Placebo challenge | 15 | 4 | |||
Vomiting/reflux, n (%) | 19 (49%) | 8 (44%) | NS | ||
During CM challenge | 0 | 3 | NS | ||
Placebo challenge | 7 | 2 | |||
Constipation, n (%) | 10 (26%) | 2 (11%) | NS | ||
During CM challenge | 0 | 0 | NS | ||
Placebo challenge | 0 | 0 | |||
Skin eruptions, n(%) | 10 (26%) | 5 (28%) | NS | ||
During CM challenge | 2 | 2 | NS | ||
Placebo challenge | 2 | 3 | |||