| |
Type of reaction
|
Type of challenge
|
Post-challenge s-IgE
|
|---|
|
Patient no.
|
Case history
|
Challenge
|
Positive
|
4 weeks later
|
|---|
|
1
|
Urticaria (IR)
|
Urticaria (IR)
|
Single p.o Pen V
|
Positive
|
|
2
|
Urticaria (NIR)
|
Maculopapular rash (NIR)
|
Single p.o Pen V
|
Negative
|
|
3
|
Urticaria/angioedema (NIR)
|
Urticaria (NIR)
|
P.o.7 Pen V
|
Positive
|
|
4
|
Urticaria (NIR)
|
Urticaria (NIR)
|
P.o.7 Pen V
|
Negative
|
|
5
|
Urticaria/angioedema (IR)
|
Urticaria (IR)
|
P.o.7 DX
|
Positive
|
|
6
|
Urticaria (NIR)
|
Maculopapular rash (NIR)
|
P.o.7 DX
|
Negative
|
- Bold text indicate concordance between type of reactions eliciting primary reaction and challenge. In the three cases of positive post-challenge s-IgE (no. 1, 3, 5) concordance was found.
- In all cases, the culprit drug and the drug eliciting the clinical reaction during challenge were identical (see Table 1).
- IR: immediate reaction, NIR: nonimmediate reaction, s-IgE: serum specific IgE to penicillin, p.o.7: 7-day oral challenge, p.o: per oral, Pen V: phenoxymethylpenicillin, DX: dicloxacillin.
